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Oxidative stress in growth hormone transgenic coho salmon with compressed lifespan - a model for addressing aging

Artikel i vetenskaplig tidskrift
Författare Bethanie Carney Almroth
Jörgen I Johnsson
R. Devlin
Joachim Sturve
Publicerad i Free Radical Research
Volym 46
Nummer/häfte 10
Sidor 1183-1189
ISSN 1071-5762
Publiceringsår 2012
Publicerad vid Institutionen för biologi och miljövetenskap
Sidor 1183-1189
Språk en
Länkar dx.doi.org/10.3109/10715762.2012.69...
Ämnesord antioxidants, molecular damage, metabolism, rate of living, fish, growth, transgenic, GH, oxygen species production, free-radical theory, oncorhynchus-tshawytscha, fillets, microtiter plate assay, 15 degrees-c, rainbow-trout, body-composition, drosophila-melanogaster, caenorhabditis-elegans, glutathione-reductase, r wc, 1992, archives of biochemistry and biophysics, v297, p35, rlin l, 1980, toxicology and applied pharmacology, v54, p420, vlin rh, 1994, nature, v371, p209
Ämneskategorier Zoofysiologi

Sammanfattning

Growth hormone (GH) transgenic fish have dramatically enhanced growth rates, increased oxygen demands and reactive oxygen species production. GH-transgenic coho salmon provide an opportunity to address effects of increased metabolism on physiological aging. The objective of this study was to compare oxidative stress in wild-type (WT) and GH-transgenic (T) coho salmon (Oncorhynchus kisutch) of different ages (1 and 2 years). Antioxidant enzyme activity, protein carbonyls (PC) and glutathione (GSH, GSSG) were measured. PC correlated to growth rates in individual fish. T fish exhibited lower antioxidant enzyme activities and GSH levels compared to the WT, while levels of PC and GSSG were higher. Age affects were observed in both WT and T fish; enzyme activities and GSH decreased while PC and GSSG increased. Our results support the metabolic rate theory of aging. This study aims to be a platform for continued studies of the theories of aging using fish as model organisms.

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