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Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling

Artikel i vetenskaplig tidskrift
Författare Margareta Scharin Täng
Björn Redfors
Malin Lindbom
Johan Svensson
Truls Råmunddal
Claes Ohlsson
Yangzhen Shao
Elmir Omerovic
Publicerad i Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Volym 22
Nummer/häfte 6
Sidor 206-211
ISSN 1096-6374
Publiceringsår 2012
Publicerad vid Wallenberglaboratoriet
Centre for Bone and Arthritis Research
Sidor 206-211
Språk en
Länkar dx.doi.org/10.1016/j.ghir.2012.09.0...
Ämneskategorier Kardiologi, Kardiovaskulär medicin

Sammanfattning

IGF-1 plays an important role in cardiovascular homeostasis, and plasma levels of IGF-1 correlate inversely with systolic function in heart failure. It is not known to what extent circulating IGF-1 secreted by the liver and local autocrine/paracrine IGF-1 expressed in the myocardium contribute to these beneficial effects on cardiac function and morphology. In the present study, we used a mouse model of liver-specific inducible deletion of the IGF-1 gene (LI-IGF-1 -/- mouse) in an attempt to evaluate the importance of circulating IGF-I on cardiac morphology and function under normal and pathological conditions, with an emphasis on its regulatory role in myocardial phosphocreatine metabolism. Echocardiography was performed in LI-IGF-1 -/- and control mice at rest and during dobutamine stress, both at baseline and post myocardial infarction (MI). High-energy phosphate metabolites were compared between LI-IGF-1 -/- and control mice at 4weeks post MI. We found that LI-IGF-1 -/- mice had significantly greater left ventricular dimensions at baseline and showed a greater relative increase in cardiac dimensions, as well as deterioration of cardiac function, post MI. Myocardial creatine content was 17.9% lower in LI-IGF-1 -/- mice, whereas there was no detectable difference in high-energy nucleotides. These findings indicate an important role of circulating IGF-1 in preserving cardiac structure and function both in physiological settings and post MI.

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