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Calbindin immunoreactivity in the enteric nervous system of larval and adult zebrafish (Danio rerio)

Artikel i vetenskaplig tidskrift
Författare Catharina Olsson
Publicerad i CELL AND TISSUE RESEARCH
Volym 344
Nummer/häfte 1
Sidor 31-40
ISSN 0302-766X
Publiceringsår 2011
Publicerad vid Zoologiska institutionen, zoofysiologi
Sidor 31-40
Språk en
Länkar dx.doi.org/10.1007/s00441-011-1135-...
Ämnesord enteric innervation, immunohistochemistry, choline acetyltransferase, serotonin, zebrafish, danio rerio (teleostei)
Ämneskategorier Zoofysiologi

Sammanfattning

Calbindin is a calcium-binding protein, commonly found in certain subpopulations of the enteric nervous system in mammals. Recently, calbindin-immunoreactive enteric neurons have also been demonstrated in shorthorn sculpin (Myoxocephalus scorpius). In the present study, calbindin immunoreactivity has been investigated in the gut of adult and larval zebrafish (Danio rerio) and differences and similarities between the two species are discussed. Calbindin immunoreactivity is present in 40%-50% of all enteric neurons in adult zebrafish. It first appears at 3 days post-fertilisation (dpf) and is present in all regions of the gut by 13 dpf. Calbindin-immunoreactive nerve cell bodies do not differ in size from calbindin-negative cells. Zebrafish calbindin-immunoreactive neurons are serotonin-negative, with at least some being choline acetyltransferase (ChAT)-positive, in contrast to the sculpin in which cells are generally smaller than the average enteric neuron and are serotonin-positive and ChAT-negative. These findings further emphasise the importance of comparative studies for understanding the diversity of chemical coding in the enteric nervous system of fish and other vertebrates. Improved knowledge of the role of the enteric nervous system is also essential for future studies of gut activity with regard to zebrafish being used as a model organism.

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