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Prophylactic treatment of local reactions to i.v. vinorelbine: a randomized study

Artikel i vetenskaplig tidskrift
Författare Eva Quant
Bengt Bergman
Publicerad i Supportive Care in Cancer
Volym 20
Nummer/häfte 8
Sidor 1737-1744
ISSN 0941-4355
Publiceringsår 2012
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin
Sidor 1737-1744
Språk en
Länkar dx.doi.org/10.1007/s00520-011-1267-...
Ämnesord Lung cancer, Vinorelbine, Local reactions, Betamethasone, cell lung-cancer, management, cisplatin, trial
Ämneskategorier Cancer och onkologi, Invärtesmedicin

Sammanfattning

Local reactions on the site of infusion are common with i.v. vinorelbine treatment. The study aims were to evaluate whether an i.v. saline infusion or steroid injection, or the combination of these measures, could decrease vinorelbine-related local reactions and to study to what extent such reactions actually occur. Patients with lung cancer and planned chemotherapy containing i.v. vinorelbine were randomized in a 2 x 2 factorial design to receive either 4 mg betamethasone or placebo i.v. prior to and either 20 or 250 ml saline infusion following the vinorelbine infusion. Local infusion site signs and symptoms were recorded during and 1 h after the vinorelbine infusion and collected by a study-specific diary 24-48 h following each treatment course. A total of 79 patients were randomized and evaluable. Local infusion site signs, symptoms and reactions occurred in 63% of all patients (49% during vinorelbine monotherapy courses), with local pain being most frequently reported. Pre-treatment with i.v. betamethasone was associated with a reduced risk of local pain (5/38 vs. 20/39; p < 0.001) or any symptoms (14/38 vs. 29/39; p = 0.01) compared with placebo during the 48 h following the vinorelbine infusion. The reduced pain effect was seen both during vinorelbine monotherapy courses and during combination chemotherapy with carboplatin. In contrast, there was no difference between post-treatment infusion with 20 or 250 ml saline with regard to local signs or symptoms. Local infusion site side effects are common with i.v. vinorelbine. Pre-treatment with 4 mg betamethasone i.v. is associated with a reduced risk of local symptoms or reactions, local pain in particular.

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