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Biocompatibility and resorption of a radiopaque premixed calcium phosphate cement

Artikel i vetenskaplig tidskrift
Författare Jonas Åberg
Helena Barreto Henriksson
Håkan Engqvist
Anders Palmquist
Camilla Brantsing
Anders Lindahl
Peter Thomsen
Helena Brisby
Publicerad i Journal of Biomedical Materials Research part A
Volym 100
Nummer/häfte 5
Sidor 1269-78
ISSN 1552-4965
Publiceringsår 2012
Publicerad vid Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin
Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Institutionen för kliniska vetenskaper, Avdelningen för ortopedi
Sidor 1269-78
Språk en
Länkar dx.doi.org/10.1002/jbm.a.34065
Ämnesord Calcium phosphate cements , bone formation
Ämneskategorier Immunbiologi, Biomaterialvetenskap

Sammanfattning

Calcium phosphate cements (CPC) are used as bone void filler in various orthopedic indications; however, there are some major drawbacks regarding mixing, transfer, and injection of traditional CPC. By using glycerol as mixing liquid, a premixed calcium phosphate cement (pCPC), some of these difficulties can be overcome. In the treatment of vertebral fractures the handling characteristics need to be excellent including a high radio-opacity for optimal control during injection. The aim of this study is to evaluate a radiopaque pCPC regarding its resorption behavior and biocompatibility in vivo. pCPC and a water-based CPC were injected into a Ø 4-mm drilled femur defect in rabbits. The rabbits were sacrificed after 2 and 12 weeks. Cross sections of the defects were evaluated using histology, electron microscopy, and immunohistochemical analysis. Signs of inflammation were evaluated both locally and systemically. The results showed a higher bone formation in the pCPC compared to the water-based CPC after 2 weeks by expression of RUNX-2. After 12 weeks most of the cement had been resorbed in both groups. Both materials were considered to have a high biocompatibility since no marked immunological response was induced and extensive bone ingrowth was observed. The conclusion from the study was that pCPC with ZrO2 radiopacifier is a promising alternative regarding bone replacement material and may be suggested for treatment of, for example, vertebral fractures based on its high biocompatibility, fast bone ingrowth, and good handling properties. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.

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