Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

The inner of the two Muc2… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.

Artikel i vetenskaplig tidskrift
Författare Malin E V Johansson
Mia Phillipson
Joel Petersson
Anna Velcich
Lena Holm
Gunnar C. Hansson
Publicerad i Proceedings of the National Academy of Sciences of the United States of America
Volym 105
Nummer/häfte 39
Sidor 15064-9
ISSN 1091-6490
Publiceringsår 2008
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 15064-9
Språk en
Länkar dx.doi.org/10.1073/pnas.0803124105
Ämnesord Animals, Colitis, genetics, immunology, microbiology, Colon, cytology, immunology, metabolism, microbiology, Intestinal Mucosa, cytology, immunology, metabolism, microbiology, Mice, Mice, Mutant Strains, Mucin-2, Mucins, genetics, physiology, Mucus, cytology, immunology, metabolism, microbiology, Rats, Rats, Sprague-Dawley, Symbiosis, genetics
Ämneskategorier Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Sammanfattning

We normally live in symbiosis with approximately 10(13) bacteria present in the colon. Among the several mechanisms maintaining the bacteria/host balance, there is limited understanding of the structure, function, and properties of intestinal mucus. We now demonstrate that the mouse colonic mucus consists of two layers extending 150 mum above the epithelial cells. Proteomics revealed that both of these layers have similar protein composition, with the large gel-forming mucin Muc2 as the major structural component. The inner layer is densely packed, firmly attached to the epithelium, and devoid of bacteria. In contrast, the outer layer is movable, has an expanded volume due to proteolytic cleavages of the Muc2 mucin, and is colonized by bacteria. Muc2(-/-) mice have bacteria in direct contact with the epithelial cells and far down in the crypts, explaining the inflammation and cancer development observed in these animals. These findings show that the Muc2 mucin can build a mucus barrier that separates bacteria from the colon epithelia and suggest that defects in this mucus can cause colon inflammation.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?