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The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions.

Artikel i vetenskaplig tidskrift
Författare Malin E V Johansson
Jessica Holmén Larsson
Gunnar C. Hansson
Publicerad i Proceedings of the National Academy of Sciences of the United States of America
Volym 108 Suppl 1
Sidor 4659-65
ISSN 1091-6490
Publiceringsår 2011
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 4659-65
Språk en
Länkar dx.doi.org/10.1073/pnas.1006451107
Ämnesord Animals, Colon, anatomy & histology, microbiology, Glycosylation, Goblet Cells, cytology, secretion, Humans, Intestinal Mucosa, cytology, metabolism, microbiology, Metagenome, Mice, Models, Biological, Mucin-2, biosynthesis, chemistry, metabolism, Symbiosis
Ämneskategorier Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Sammanfattning

The normal intestinal microbiota inhabits the colon mucus without triggering an inflammatory response. The reason for this and how the intestinal mucus of the colon is organized have begun to be unraveled. The mucus is organized in two layers: an inner, stratified mucus layer that is firmly adherent to the epithelial cells and approximately 50 μm thick; and an outer, nonattached layer that is usually approximately 100 μm thick as measured in mouse. These mucus layers are organized around the highly glycosylated MUC2 mucin, forming a large, net-like polymer that is secreted by the goblet cells. The inner mucus layer is dense and does not allow bacteria to penetrate, thus keeping the epithelial cell surface free from bacteria. The inner mucus layer is converted into the outer layer, which is the habitat of the commensal flora. The outer mucus layer has an expanded volume due to proteolytic activities provided by the host but probably also caused by commensal bacterial proteases and glycosidases. The numerous O-glycans on the MUC2 mucin not only serve as nutrients for the bacteria but also as attachment sites and, as such, probably contribute to the selection of the species-specific colon flora. This observation that normal human individuals carry a uniform MUC2 mucin glycan array in colon may indicate such a specific selection.

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