Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Modelling of peripheral f… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Modelling of peripheral fluid accumulation after a crystalloid bolus in female volunteers - a mathematical study

Artikel i vetenskaplig tidskrift
Författare P. Rodhe
D. Drobin
R.G. Hahn
Bernt Wennberg
C. Lindahl
F. Sjöstrand
C.H. Svensen
Publicerad i Computational and Mathematical Methods in Medicine
Volym 11
Nummer/häfte 4
Sidor 341-351
ISSN 1748-670X
Publiceringsår 2010
Publicerad vid Institutionen för matematiska vetenskaper, matematik
Sidor 341-351
Språk en
Länkar dx.doi.org/10.1080/1748670X.2010.49...
https://gup.ub.gu.se/file/64995
Ämnesord anaesthesia, fluids, kinetics, modelling, peripheral space
Ämneskategorier Annan matematik

Sammanfattning

Objective. To simultaneously model plasma dilution and urinary output in female volunteers. Methods. Ten healthy female non-pregnant volunteers, aged 21-39 years (mean 29), with a bodyweight of 58-67kg (mean 62.5kg) participated. No oral fluid or food was allowed between midnight and completion of the experiment. The protocol included an infusion of acetated Ringer's solution, 25ml/kg over 30min. Blood samples (4ml) were taken every 5min during the first 120min, and thereafter the sampling rate was every 10min until the end of the experiment at 240min. A standard bladder catheter connected to a drip counter to monitor urine excretion continuously was used. The data were analysed by empirical calculations as well as by a mathematical model. Results. Maximum urinary output rate was found to be 19 (13-31) ml/min. The subjects were likely to accumulate three times as much of the infused fluid peripherally as centrally; 1/=2.7 (2.0-5.7). Elimination efficacy, Eeff, was 24 (5-35), and the basal elimination kb was 1.11 (0.28-2.90). The total time delay Ttot of urinary output was estimated as 17 (11-31) min. Conclusion. The experimental results showed a large variability in spite of a homogenous volunteer group. It was possible to compute the infusion amount, plasma dilution and simultaneous urinary output for each consecutive time point and thereby the empirical peripheral fluid accumulation. The variability between individuals may be explained by differences in tissue and hormonal responses to fluid boluses, which needs to be further explored.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?