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Baroreflex control of muscle sympathetic nerve activity: a nonpharmacological measure of baroreflex sensitivity.

Artikel i vetenskaplig tidskrift
Författare Emma C Hart
Michael J Joyner
Gunnar B Wallin
Tomas Karlsson
Timothy B Curry
Nisha Charkoudian
Publicerad i American journal of physiology. Heart and circulatory physiology
Volym 298
Nummer/häfte 3
Sidor H816-22
ISSN 1522-1539
Publiceringsår 2010
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor H816-22
Språk en
Länkar dx.doi.org/10.1152/ajpheart.00924.2...
Ämnesord Adult, Baroreflex, physiology, Blood Pressure, drug effects, physiology, Female, Humans, Male, Muscle, Skeletal, innervation, physiology, Nitroprusside, pharmacology, Phenylephrine, pharmacology, Sensitivity and Specificity, Sympathetic Nervous System, physiology, Vasoconstrictor Agents, pharmacology, Vasodilator Agents, pharmacology
Ämneskategorier Klinisk neurofysiologi

Sammanfattning

The sensitivity of baroreflex control of sympathetic nerve activity (SNA) represents the responsiveness of SNA to changes in blood pressure. In a slightly different analysis, the baroreflex threshold measures the probability of whether a sympathetic burst will occur at a given diastolic blood pressure. We hypothesized that baroreflex threshold analysis could be used to estimate the sensitivity of the sympathetic baroreflex measured by the pharmacological modified Oxford test. We compared four measures of sympathetic baroreflex sensitivity in 25 young healthy participants: the "gold standard" modified Oxford analysis (nitroprusside and phenylephrine), nonbinned spontaneous baroreflex analysis, binned spontaneous baroreflex analysis, and threshold analysis. The latter three were performed during a quiet baseline period before pharmacological intervention. The modified Oxford baroreflex sensitivity was significantly related to the threshold slope (r = 0.71, P < 0.05) but not to the binned (1 mmHg bins) and the nonbinned spontaneous baroreflex sensitivity (r = 0.22 and 0.36, respectively, P > 0.05), which included burst area. The threshold analysis was also performed during the modified Oxford manipulation. Interestingly, we found that the threshold analysis results were not altered by the vasoactive drugs infused for the modified Oxford. We conclude that the noninvasive threshold analysis technique can be used as an indicator of muscle SNA baroreflex sensitivity as assessed by the modified Oxford technique. Furthermore, the modified Oxford method does not appear to alter the properties of the baroreflex.

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