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Blood pressure regulation in humans: calculation of an "error signal" in control of sympathetic nerve activity.

Artikel i vetenskaplig tidskrift
Författare Erica A Wehrwein
Michael J Joyner
Emma C J Hart
Gunnar B Wallin
Tomas Karlsson
Nisha Charkoudian
Publicerad i Hypertension
Volym 55
Nummer/häfte 2
Sidor 264-9
ISSN 1524-4563
Publiceringsår 2010
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor 264-9
Språk en
Länkar dx.doi.org/10.1161/HYPERTENSIONAHA....
Ämnesord Adult, Blood Flow Velocity, Blood Pressure, physiology, Blood Pressure Determination, Cardiac Output, physiology, Cohort Studies, Female, Hemodynamics, physiology, Humans, Male, Muscle, Skeletal, innervation, physiology, Muscle, Smooth, Vascular, innervation, physiology, Reference Values, Retrospective Studies, Sex Factors, Sympathetic Nervous System, physiology, Vascular Resistance, physiology
Ämneskategorier Klinisk neurofysiologi

Sammanfattning

Within an individual, diastolic blood pressure (DBP) is negatively related to sympathetic burst incidence, such that lower pressure is associated with high burst incidence. Our goal was to explore the use of a calculation of a DBP "error signal" in the control of muscle sympathetic nerve activity in men and women. Baseline muscle sympathetic nerve activity was measured in healthy young men (n=22) and women (n=28). Women had significantly lower muscle sympathetic nerve activity than men (29+/-3 versus 43+/-2 bursts per 100 heartbeats; P<0.05). For each individual, the DBP at which there is a 50% likelihood of a muscle sympathetic nerve activity burst, the "T50" value, was calculated. Mean DBP was subtracted from the T50 blood pressure as an approximate error signal for burst activation. Error signal was negative in both sexes, indicating that DBP in both sexes was higher than the DBP value associated with a 50% burst likelihood. However, average error signal was significantly larger in women (-4+/-2 mm Hg) than in men (-1+/-0 mm Hg; P<0.05 versus women). We conclude that women operate at a mean DBP greater than their T50 compared with men, and this may be a contributing factor to low basal muscle sympathetic nerve activity in women. The relationship between error signal and burst incidence may provide important insight into the control of muscle sympathetic nerve activity across sexes and in various populations.

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