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Effects of growth hormone treatment on the leptin system and on energy expenditure in abdominally obese men.

Artikel i vetenskaplig tidskrift
Författare C Karlsson
Kaj Stenlöf
Gudmundur Johannsson
P Mårin
Per Björntorp
B A Bengtsson
Björn Carlsson
Lena M S Carlsson
Lars Sjöström
Publicerad i European journal of endocrinology / European Federation of Endocrine Societies
Volym 138
Nummer/häfte 4
Sidor 408-14
ISSN 0804-4643
Publiceringsår 1998
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi
Institutionen för invärtesmedicin
Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism
Sidor 408-14
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Abdomen, Aged, Double-Blind Method, Energy Metabolism, drug effects, Growth Hormone, therapeutic use, Humans, Insulin-Like Growth Factor I, metabolism, Leptin, Male, Middle Aged, Obesity, blood, drug therapy, Proteins, metabolism, Regression Analysis, Thyroid Hormones, blood, Time Factors, Treatment Outcome
Ämneskategorier Endokrinologi

Sammanfattning

The present study has examined the short- and long-term effects of growth hormone (GH) treatment on the leptin system and energy expenditure. Thirty male individuals with abdominal obesity were randomised to GH or placebo treatment in a 9-month, double-blind study. The dose of GH was 9.5 microg/kg, administered subcutaneously every evening. Serum leptin concentrations were measured by a human leptin RIA. Total RNA was isolated from adipose tissue biopsies and leptin mRNA levels were determined by a semi-quantitative reverse transcriptase-PCR assay. Body composition was determined by potassium-40 and the basal metabolic rate (BMR) was measured by a computerised, ventilated, open-hood system. As compared with placebo, an overall decrease in serum leptin concentrations as assessed by the area under the curve (AUC) (P < 0.05) and an increase in BMR (AUC, P < 0.05) were observed during GH treatment. The overall GH-induced changes were due to marked changes in serum leptin concentrations and BMR after 6 weeks of treatment. After 9 months of GH treatment there was a significant reduction in body fat (BF) while serum leptin concentrations and BMR did not differ from baseline values. Leptin mRNA levels did not change over the study period. We speculate that long-term GH treatment induces a new energy balance steady state with decreased BF stores. The effects of GH on the leptin system is suggested to be of importance for the maintenance of a lower BF mass.

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