Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Estramustine induces diso… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Estramustine induces disorganization of microtubules, perinuclear retraction of vimentin and endoplasmatic reticulum, and inhibits cell migration.

Artikel i vetenskaplig tidskrift
Författare M Rutberg
Margareta Wallin
Publicerad i Acta histochemica
Volym 95
Nummer/häfte 2
Sidor 155-67
ISSN 0065-1281
Publiceringsår 1993
Publicerad vid Zoologiska institutionen
Sidor 155-67
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Cell Adhesion, drug effects, Cell Line, Cell Movement, drug effects, Cell Nucleus, drug effects, metabolism, ultrastructure, Cell Survival, drug effects, Endoplasmic Reticulum, drug effects, ultrastructure, Estramustine, administration & dosage, pharmacology, Humans, Immunohistochemistry, Microscopy, Electron, Scanning, Microtubules, drug effects, ultrastructure, Vimentin, immunology, metabolism, Vinblastine, pharmacology
Ämneskategorier Cell- och molekylärbiologi

Sammanfattning

The effects of the mitotic inhibitor estramustine on the cytoskeleton of DU 145 and AG 1518 cells were studied. Estramustine caused a partial disassembly of microtubules and withdrawal of microtubules from the cell periphery, disorganized microtubules and delayed regrowth of disassembled microtubules. It also induced a spheroid cellular morphology and affected cellular adhesion and survival. Sometimes microtubules seemed to be organized from several microtubule-organizing centers. The cytoskeleton-dependent cell migration was inhibited in the presence of estramustine and the microtubule-interacting vimentin and endoplasmatic reticulum retracted to the perinuclear area. Our results show that not only a complete disassembly of microtubules, but also disturbances of the microtubule network can have dramatic effects on microtubule-dependent processes and localization of cellular organelles. These effects could be of importance in the treatment of prostatic carcinoma with estramustine.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?