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Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals.

Artikel i vetenskaplig tidskrift
Författare Jayne V Brian
Catherine A Harris
Martin Scholze
Thomas Backhaus
Petra Booy
Marja Lamoree
Giulio Pojana
Niels Jonkers
Tamsin Runnalls
Angela Bonfà
Antonio Marcomini
John P Sumpter
Publicerad i Environmental health perspectives
Volym 113
Nummer/häfte 6
Sidor 721-8
ISSN 0091-6765
Publiceringsår 2005
Publicerad vid Botaniska institutionen, fysiologisk botanik
Sidor 721-8
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Cyprinidae, Drug Synergism, Estradiol, toxicity, Estrogens, toxicity, Estrogens, Non-Steroidal, toxicity, Ethinyl Estradiol, toxicity, Female, Forecasting, Fresh Water, Male, Phenols, toxicity, Vitellogenins, biosynthesis, blood, Water Pollutants, Chemical, toxicity
Ämneskategorier Miljökemi, Miljötoxikologi, Biologiska vetenskaper, Biokemi, Toxikologi, Ekologi, Limnisk ekologi, Marin ekologi, Toxikologi, Naturvetenskap

Sammanfattning

Existing environmental risk assessment procedures are limited in their ability to evaluate the combined effects of chemical mixtures. We investigated the implications of this by analyzing the combined effects of a multicomponent mixture of five estrogenic chemicals using vitellogenin induction in male fathead minnows as an end point. The mixture consisted of estradiol, ethynylestradiol, nonylphenol, octylphenol, and bisphenol A. We determined concentration-response curves for each of the chemicals individually. The chemicals were then combined at equipotent concentrations and the mixture tested using fixed-ratio design. The effects of the mixture were compared with those predicted by the model of concentration addition using biomathematical methods, which revealed that there was no deviation between the observed and predicted effects of the mixture. These findings demonstrate that estrogenic chemicals have the capacity to act together in an additive manner and that their combined effects can be accurately predicted by concentration addition. We also explored the potential for mixture effects at low concentrations by exposing the fish to each chemical at one-fifth of its median effective concentration (EC50). Individually, the chemicals did not induce a significant response, although their combined effects were consistent with the predictions of concentration addition. This demonstrates the potential for estrogenic chemicals to act additively at environmentally relevant concentrations. These findings highlight the potential for existing environmental risk assessment procedures to underestimate the hazard posed by mixtures of chemicals that act via a similar mode of action, thereby leading to erroneous conclusions of absence of risk.

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