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Premixed acidic calcium phosphate cement: Characterization of strength and microstructure.

Artikel i vetenskaplig tidskrift
Författare Jonas Åberg
Helena Brisby
Helena Barreto Henriksson
Anders Lindahl
Peter Thomsen
Håkan Engqvist
Publicerad i Journal of biomaterials research. Part B. Applied biomaterials
Volym 93
Nummer/häfte 2
Sidor 436-41
ISSN 1552-4981
Publiceringsår 2010
Publicerad vid Institutionen för biomedicin
Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Institutionen för kliniska vetenskaper, Avdelningen för ortopedi
Sidor 436-41
Språk en
Länkar dx.doi.org/10.1002/jbm.b.31600
Ämneskategorier Biomaterialvetenskap, Klinisk medicin


By using a premixed calcium phosphate cement (CPC), the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPCs. Previously premixed cements have been based on apatitic cements. In this article, acidic cement has been developed and evaluated. Monocalcium phosphate monohydrate and beta-tricalcium phosphate were mixed with glycerol to form a paste. As the paste does not contain water, no setting reaction starts and thus the working time is indefinite. Powder/liquid ratios (P/L) of 2.25, 3.5 and 4.75 were evaluated. Setting time (ST) and compressive strength (CS) were measured after 1 day, 1 week and 4 weeks in phosphate buffered saline (PBS) solution, and the corresponding microstructure was evaluated using electron microscopy and X-ray diffraction. The ST started when the cements were placed in PBS and ranged from 28 to 75 min, higher P/L gave a lower ST. Higher P/L also gave a higher CS, which ranged from 2 to 16 MPa. The microstructure mainly consisted of monetite, 1-5 mum in grain size. After 4 weeks in PBS, the strength increased. As acidic cements are resorbed faster in vivo, this cement should allow faster bone regeneration than apatitic cements. Premixed cements show a great handling benefit when compared with normal CPCs and can be formulated with similar ST and mechanical properties. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2010.

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