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The haptoglobin 2-2 genotype is associated with carotid atherosclerosis in 64-year old women with established diabetes.

Artikel i vetenskaplig tidskrift
Författare Mikael Ryndel
Carl Johan Behre
Gerhard Brohall
Ulrica Prahl
Caroline Schmidt
Göran Bergström
Björn Fagerberg
Fredrik J. Olson
Publicerad i Clinica chimica acta; international journal of clinical chemistry
ISSN 1873-3492
Publiceringsår 2010
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Språk en
Länkar dx.doi.org/10.1016/j.cca.2009.12.02...
Ämnesord Arteriosclerosis, Cardiovascular risk factors, Carotid intima-media thickness, Diabetes mellitus, Haptoglobin, Polymorphism
Ämneskategorier Medicin och Hälsovetenskap, Klinisk fysiologi, Kardiovaskulär medicin, Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Sammanfattning

BACKGROUND: Haptoglobin polymorphism generates three common human genotypes: Hp1-1, Hp2-1 and Hp2-2. Among subjects with diabetes, Hp2-2 is associated with an elevated risk to develop cardiovascular disease. The impact of haptoglobin genotype on subclinical carotid atherosclerosis is not known. We hypothesised that Hp2-2 was associated with increased occurrence of carotid atherosclerosis in subjects with diabetes. METHODS: We studied a population-based sample of 64-year old women with diabetes (n=226), either established diabetes known before study entry (n=116) or new diabetes detected at study screening. Haptoglobin genotype was determined by PCR. Carotid atherosclerosis was assessed by ultrasound imaging. RESULTS: In the entire diabetes cohort, no differences were observed in carotid intima-media thickness (IMT) or plaque prevalence between the genotype groups. However, among those with established diabetes, Hp2-2 was associated with higher plaque prevalence and larger carotid IMT compared with the Hp2-1 and Hp1-1 genotypes. Common cardiovascular risk factors did not differ between the genotype groups. CONCLUSIONS: The Hp2-2 genotype was associated with increased occurrence of subclinical carotid atherosclerosis in 64-year old women with established diabetes. This association was not explained by traditional risk factors for cardiovascular disease. These results extend previous observations that Hp2-2 is associated with clinical cardiovascular disease in diabetes.

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