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A single early postnatal estradiol injection affects morphology and gene expression of the ovary and parametrial adipose tissue in adult female rats.

Artikel i vetenskaplig tidskrift
Författare Camilla Alexanderson
Elisabet Stener-Victorin
Joel Kullberg
Staffan Nilsson
Max Levin
Stefan Cajander
Lars Lönn
Malin Lönn
Agneta Holmäng
Publicerad i The Journal of steroid biochemistry and molecular biology
Volym 122
Nummer/häfte 1-3
Sidor 82-90
ISSN 1879-1220
Publiceringsår 2010
Publicerad vid Wallenberglaboratoriet
Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för matematiska vetenskaper, matematisk statistik
Sidor 82-90
Språk en
Länkar dx.doi.org/10.1016/j.jsbmb.2009.10....
Ämnesord Estradiol; Programming; Ovary; Parametrial adipose tissue
Ämneskategorier Fysiologi

Sammanfattning

Events during early life can affect reproductive and metabolic functions in adulthood. We evaluated the programming effects of a single early postnatal estradiol injection (within 3h after birth) in female rats. We assessed ovarian and parametrial adipose tissue morphology, evaluated gene expression related to follicular development and adipose tissue metabolism, and developed a non-invasive volumetric estimation of parametrial adipose tissue by magnetic resonance imaging. Estradiol reduced ovarian weight, increased antral follicle size and number of atretic antral follicles, and decreased theca interna thickness in atretic antral follicles. Adult estradiol-injected rats also had malformed vaginal openings and lacked corpora lutea, confirming anovulation. Estradiol markedly reduced parametrial adipose tissue mass. Adipocyte size was unchanged, suggesting reduced adipocyte number. Parametrial adipose tissue lipoprotein lipase activity was increased. In ovaries, estradiol increased mRNA expression of adiponectin, complement component 3, estrogen receptor alpha, and glucose transporter 3 and 4; in parametrial adipose tissue, expression of complement component 3 was increased, expression of estrogen receptor alpha was decreased, and expression of leptin, lipoprotein lipase, and hormone-sensitive lipase was unaffected. These findings suggest that early postnatal estradiol exposure of female rats result in long-lasting effects on the ovary and parametrial adipose tissue at adult age.

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