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The effect of a triclosan dentifrice on mucositis in subjects with dental implants: a six-month clinical study

Artikel i vetenskaplig tidskrift
Författare Per Ramberg
Jan Lindhe
Daniele Botticelli
Antonella Botticelli
Publicerad i Journal of Clinical Dentistry
Volym 20
Nummer/häfte 3
Sidor 103-7
ISSN 0895-8831
Publiceringsår 2009
Publicerad vid Institutionen för odontologi
Sidor 103-7
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Peri-implant mucositis, dentifrice, triclosan
Ämneskategorier Parodontologi


OBJECTIVE: The objective of the present clinical study was to assess the effect of the use of a dentifrice containing triclosan on peri-implant mucositis in subjects that had been restored with dental implants. METHODS: The trial was designed as a double-blind, randomized, two-treatment, parallel-group clinical study. Sixty male and female subjects, aged 30-70 years, were recruited. All subjects had lost teeth due to periodontal disease, and had been restored with a minimum of two implants at least one year prior to the start of the trial. Subjects were randomly assigned to two treatment groups. The subjects in the test group (Test) brushed their teeth and implant-supported restorations with a dentifrice containing triclosan, while the control subjects brushed with a sodium fluoride dentifrice. Only subjects with a minimum of one implant site showing clinical signs of peri-implant mucositis, i.e., bleeding after probing, were enrolled in the study. Clinical examinations were performed at baseline, and after three and six months. The following parameters were scored: Probing pocket depth (PPD), bleeding on probing (BoP), and plaque. The change from baseline within each treatment group at three months and six months was evaluated for all parameters using ANOVA and ANCOVA. RESULTS: Subjects with peri-implant mucositis who used a dentifrice containing 0.3% triclosan, as an adjunct to mechanical tooth brushing, exhibited significantly fewer clinical signs of inflammation than subjects who used a regular fluoride dentifrice at six months. The BoP scores were reduced from 53.8% to 29.1% in the Test group, whereas in the same interval there was an increase from 52.3% to 58.8% in the Control group. Furthermore, the individual mean PPD, as well as the frequency of sites with 5 mm and > or = 6 mm deep pockets, were reduced significantly more in the Test than in the Control group. CONCLUSION: The regular use of a dentifrice containing triclosan may reduce the clinical signs of inflammation in the mucosa adjacent to dental implants.

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