Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Cold-stable and cold-adap… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Cold-stable and cold-adapted microtubules.

Forskningsöversiktsartikel
Författare Margareta Wallin
E Strömberg
Publicerad i International review of cytology
Volym 157
Sidor 1-31
ISSN 0074-7696
Publiceringsår 1995
Publicerad vid Zoologiska institutionen
Sidor 1-31
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adaptation, Physiological, drug effects, Animals, Body Temperature Regulation, physiology, Cold Temperature, Microtubule-Associated Proteins, drug effects, physiology, Microtubules, drug effects, physiology, Paclitaxel, pharmacology, Plant Physiological Phenomena, Structure-Activity Relationship
Ämneskategorier Cell- och molekylärbiologi

Sammanfattning

Most mammalian microtubules disassemble at low temperature, but some are cold stable. This probably has little to do with a need for cold-stable microtubules, but reflects that certain populations of microtubules must be stabilized for specific functions. There are several routes by which to achieve cold stability. Factors that interact with microtubules, such as microtubule-associated proteins, STOPs (stable tubule only polypeptides), histones, and possibly capping factors, are involved. Specific tubulin isotypes and posttranslational modifications might also be of importance. More permanent stable microtubules can be achieved by bundling factors, associations to membranes, as well as by assembly of microtubule doublets and triplets. This is, however, not the explanation for cold adaptation of microtubules from poikilothermic animals, that is, animals that must have all their microtubules adapted to low temperatures. All evidence so far suggests that cold adaptation is intrinsic to the tubulins, but it is unknown whether it depends on different amino acid sequences or posttranslational modifications.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?