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Distribution of acetylated tubulin in cultured cells and tissues from the Atlantic cod (Gadus morhua). Role of acetylation in cold adaptation and drug stability.

Artikel i vetenskaplig tidskrift
Författare M Rutberg
Martin Billger
C Modig
Margareta Wallin
Publicerad i Cell biology international
Volym 19
Nummer/häfte 9
Sidor 749-58
ISSN 1065-6995
Publiceringsår 1995
Publicerad vid Zoologiska institutionen
Sidor 749-58
Språk en
Länkar dx.doi.org/10.1006/cbir.1995.1126
Ämnesord Acetylation, Adaptation, Physiological, Animals, Cell Division, Cells, Cultured, Cold Temperature, Fishes, physiology, Microtubules, physiology, Organ Specificity, Tubulin, analysis, chemistry
Ämneskategorier Cell- och molekylärbiologi

Sammanfattning

The Atlantic cod (Gadus morhua) is a poikilothermic animal living at temperatures between 2-15 degrees C. Isolated cod brain tubulin is, in contrast to mammalian brain tubulin, posttranslationally modified by acetylation to a high extent. To investigate the role of acetylation in cold adaptation, microtubules were isolated by a taxol-dependent procedure from different organs of the cod, and cells from different tissues were cultured. All cells from skin and brain were able to grow between 4 degrees C and room temperature. Microtubules in the cultured cells were sometimes severed near the periphery of the cells. Microtubules in brain cells were in general more stable to vinblastine and colchicine, when compared to skin cells. Acetylated microtubules were found only in brain cells, in peripheral nerves on scales and in nerves of the intestinal tract and in microtubules isolated from neuronal tissue. Our results show that acetylated microtubules are found both in the central and peripheral nervous system, but that there is no correlation between acetylation and cold-adaptation.

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