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Population genomics of domestic and wild yeasts.

Artikel i vetenskaplig tidskrift
Författare Gianni Liti
David M Carter
Alan M Moses
Jonas Warringer
Leopold Parts
Stephen A James
Robert P Davey
Ian N Roberts
Austin Burt
Vassiliki Koufopanou
Isheng J Tsai
Casey M Bergman
Douda Bensasson
Michael J T O'Kelly
Alexander van Oudenaarden
David B H Barton
Elizabeth Bailes
Alex N Nguyen
Matthew Jones
Michael A Quail
Ian Goodhead
Sarah Sims
Frances Smith
Anders Blomberg
Richard Durbin
Edward J Louis
Publicerad i Nature
Volym 458
Nummer/häfte 7236
Sidor 337-41
ISSN 1476-4687
Publiceringsår 2009
Publicerad vid Institutionen för cell- och molekylärbiologi
Sidor 337-41
Språk en
Länkar dx.doi.org/10.1038/nature07743
Ämnesord Genetics, Population, Genome, Fungal, genetics, Genomics, Geography, INDEL Mutation, genetics, Phenotype, Phylogeny, Polymorphism, Single Nucleotide, genetics, Saccharomyces, classification, genetics, Saccharomyces cerevisiae, genetics, Selection (Genetics)
Ämneskategorier Molekylärbiologi, Cellbiologi, Genetik

Sammanfattning

Since the completion of the genome sequence of Saccharomyces cerevisiae in 1996 (refs 1, 2), there has been a large increase in complete genome sequences, accompanied by great advances in our understanding of genome evolution. Although little is known about the natural and life histories of yeasts in the wild, there are an increasing number of studies looking at ecological and geographic distributions, population structure and sexual versus asexual reproduction. Less well understood at the whole genome level are the evolutionary processes acting within populations and species that lead to adaptation to different environments, phenotypic differences and reproductive isolation. Here we present one- to fourfold or more coverage of the genome sequences of over seventy isolates of the baker's yeast S. cerevisiae and its closest relative, Saccharomyces paradoxus. We examine variation in gene content, single nucleotide polymorphisms, nucleotide insertions and deletions, copy numbers and transposable elements. We find that phenotypic variation broadly correlates with global genome-wide phylogenetic relationships. S. paradoxus populations are well delineated along geographic boundaries, whereas the variation among worldwide S. cerevisiae isolates shows less differentiation and is comparable to a single S. paradoxus population. Rather than one or two domestication events leading to the extant baker's yeasts, the population structure of S. cerevisiae consists of a few well-defined, geographically isolated lineages and many different mosaics of these lineages, supporting the idea that human influence provided the opportunity for cross-breeding and production of new combinations of pre-existing variations.

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