Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Breast cancer incidence a… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study

Artikel i vetenskaplig tidskrift
Författare C Orgeas
Karin Sanner
Per Hall
Peter Conner
Jan Holte
Staffan Nilsson
Karin Sundfeldt
Ingemar Persson
Kee Seng Chia
Sara Wedren
Paul Dickman
Kamilla Czene
Publicerad i Am J Obstet Gynecol
Volym 200
Nummer/häfte 1
Sidor 72 e1-7
ISSN 0002-9378
Publiceringsår 2009
Publicerad vid Institutionen för kliniska vetenskaper
Sidor 72 e1-7
Språk en
Länkar dx.doi.org/10.1016/j.ajog.2008.08.0...
Ämnesord Adult, Breast Neoplasms/*chemically induced/epidemiology, Chorionic Gonadotropin/*adverse effects/therapeutic use, Clomiphene/*adverse effects/therapeutic use, Cohort Studies, Female, Fertility Agents, Female/*adverse effects/therapeutic use, Humans, Incidence, Infertility, Female/*drug therapy, Prospective Studies, Sweden/epidemiology, ovulation induction, postmenopausal women, fertility drugs, risk, therapy, health, carcinogenesis, prevention, pregnancy, estrogens
Ämneskategorier Medicin och Hälsovetenskap, Obstetrik och kvinnosjukdomar

Sammanfattning

OBJECTIVE: To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer. STUDY DESIGN: Historical prospective cohort study of 1135 women attending major university clinics for treatment of infertility in Sweden, 1961-1976. Women were classified as users of clomiphene citrate or gonadotropins, or a combination of both therapies. Standardized incidence ratios were calculated to estimate relative risk of breast cancer. RESULTS: We observed 54 cases of breast cancer during 1961-2004, which did not significantly exceed those expected. Users of high-dose clomiphene citrate had an almost 2-fold increased risk (standardized incidence ratio, 1.90; 95% confidence interval, 1.08-3.35). This association was more pronounced among women referred for nonovulatory factors, with 3-fold increased risk (standardized incidence ratio, 3.00; 95% confidence interval, 1.35-6.67). CONCLUSION: No overall increased risk for breast cancer was shown with infertility treatment. Women with nonovulatory causes treated with high-dose clomiphene citrate therapy may have an elevated risk for breast cancer.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?