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Interleukin-1 system gene polymorphisms are associated with fat mass in young men.

Artikel i vetenskaplig tidskrift
Författare Louise Strandberg
Mattias Lorentzon
Åsa Hellqvist
Staffan Nilsson
Ville Wallenius
Claes Ohlsson
John-Olov Jansson
Publicerad i The Journal of clinical endocrinology and metabolism
Volym 91
Nummer/häfte 7
Sidor 2749-54
ISSN 0021-972X
Publiceringsår 2006
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik
Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Institutionen för medicin, avdelningen för invärtesmedicin
Sidor 2749-54
Språk en
Länkar dx.doi.org/10.1210/jc.2005-2786
Ämnesord Absorptiometry, Photon, Adipose Tissue, Adolescent, Adult, Body Composition, genetics, Gene Frequency, Genotype, Humans, Interleukin 1 Receptor Antagonist Protein, Interleukin-1, genetics, Linkage Disequilibrium, Male, Minisatellite Repeats, Polymorphism, Genetic, Receptors, Interleukin-1, antagonists & inhibitors, Sialoglycoproteins, genetics
Ämneskategorier Fysiologi

Sammanfattning

CONTEXT: There is growing evidence for interactions between the regulation of body fat and the immune system. Studies of knockout mice indicate that IL-1 has an antiobesity effect. OBJECTIVE: The objective of the study was to investigate our hypothesis that common polymorphisms of the IL-1 system, which are associated with IL-1 activity, also are associated with fat mass. DESIGN, SETTING, AND STUDY SUBJECTS: The Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a population-based cross-sectional study of 18- to 20-yr-old men (n = 1068), mostly Caucasian, from the Gothenburg area (Sweden). Three different polymorphisms, IL-1beta +3953 C/T, IL-1beta-31 T/C, and IL-1 receptor antagonist (IL-1RN) variable number tandem repeat of 86 bp, were investigated in relation to body fat mass. MAIN OUTCOME MEASURE: The main outcome measures were genotype distributions and their association with body fat mass in different compartments, measured with dual-energy x-ray absorptiometry. RESULTS: Carriers of the T variant (CT and TT) of the +3953 C to T (F(T) = 0.25) IL-1beta gene polymorphism had significantly lower total fat mass (P = 0.013) and also significantly reduced arm, leg, and trunk fat, compared with CC individuals. IL-1RN*2 carriers with two repeats of the IL-1RN variable number tandem repeat polymorphism had increased total fat (P = 0.036), serum leptin, and fat of trunk and arm as well as serum levels of IL-1RN and IL-1RN production ex vivo. The IL-1beta-31 polymorphism did not correlate with the fat measurements. CONCLUSIONS: The IL-1 system, recently shown to affect fat mass in experimental animals, contains gene polymorphisms that are associated with fat mass in young men.

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http://www.gu.se/forskning/publikation/?publicationId=93824
Utskriftsdatum: 2020-07-08