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Increased nitric oxide in exhaled air after intake of a nitrate-rich meal.

Artikel i vetenskaplig tidskrift
Författare AC Olin
A Aldenbratt
Anna Ekman
Göran Ljungkvist
L Jungersten
K Alving
Kjell Torén
Publicerad i Respiratory medicine
Volym 95
Nummer/häfte 2
Sidor 153-8
ISSN 0954-6111
Publiceringsår 2001
Publicerad vid Institutionen för invärtesmedicin
Sidor 153-8
Språk en
Länkar dx.doi.org/10.1053/rmed.2000.1010
Ämnesord Adult, Arginine, blood, Biological Markers, analysis, Breath Tests, Female, Humans, Male, Nitrates, administration & dosage, blood, Nitric Oxide, analysis, Postprandial Period, Sensitivity and Specificity
Ämneskategorier Invärtesmedicin, Lungmedicin och allergi

Sammanfattning

Exhaled and nasal NO (ENO, NNO) have been suggested as markers for inflammation in lower and upper respiratory tract respectively. It is still unknown how a number of factors, apart from airway inflammation, can influence NO levels. The aim of this study was to determine the effect of a nitrate-rich meal on ENO and NNO. Sixteen healthy subjects were observed during 1 week on normal diet before a nitrate-restricted diet was introduced in the next. On day 3 of the second week they were made to ingest a nitrate rich meal. ENO, NNO, plasma nitrate and plasma L-arginine were followed before the meal and afterwards for 3 h. ENO and NNO as well as plasma nitrate and plasma L-arginine were significantly elevated after the nitrate-rich meal. The median maximal increase of ENO and NNO was 47% and 13% respectively. We found a moderate but significant correlation between the rise in plasma nitrate and ENO (r(s)=0.57, P=0.027) but none between plasma nitrate and NNO (r(s)=-0.02, P=0.95). As nitrate in the diet seems to substantially influence the levels of ENO it is important either to restrict or register the intake of nitrate-rich food prior to measuring ENO.

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http://www.gu.se/forskning/publikation/?publicationId=88169
Utskriftsdatum: 2019-10-22