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Characterization of sensitization to furry animal allergen components in an adult population.

Artikel i vetenskaplig tidskrift
Författare Shintaro Suzuki
Bright I Nwaru
Linda Ekerljung
Sigrid Sjölander
Roxana Mincheva
Erik P Rönmark
Eva Rönmark
Bo Lundbäck
Magnus P. Borres
Jan Lötvall
Publicerad i Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Volym 49
Nummer/häfte 4
Sidor 495-505
ISSN 1365-2222
Publiceringsår 2019
Publicerad vid Krefting Research Centre
Sidor 495-505
Språk en
Länkar dx.doi.org/10.1111/cea.13355
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Klinisk medicin, Hälsovetenskaper

Sammanfattning

There are paucity of data on sensitization to furry animal allergen components in adults. Furry animals are major sensitizers and contributors to asthma burden in northern Europe and North America.To characterize sensitization patterns to furry animal allergen components in Swedish adults.Based on the West Sweden Asthma Study, a random population (n = 1103) and an asthma sample (n = 769) were tested for allergen sensitization using Phadiatop® . Those with IgE ≥ 0.35 kUA /L were tested for cat (Fel d 1, 2, and 4), dog (Can f 1, 2, 3, and 5), and horse (Equ c 1) allergen component sensitization. We defined allergen component poly-sensitization patterns, identified data-driven sensitization clusters, described component sensitization overlaps, and assessed determinants of sensitization patterns.The prevalence of allergen component sensitization ranged from 0.8% for Fel d 2 and Can f 3 to 8.9% for Fel d 1. The most common dog component was Can f 5 (3.6%); 2.1% were sensitized to Equ c 1. Those sensitized to Fel d 2 and Fel d 4 were commonly sensitized to Fel d 1. The most common dog component overlap was between Can f 1/Can f 2 and Can f 5. Mono-sensitization was 5.6%, double sensitization 1.5% and poly-sensitization 2.1%. Sensitization was always higher in the asthma than in the random sample. Three sensitization clusters were derived, namely non-sensitized (90% in random vs 66% in asthma sample); Fel d 1-driven sensitized (7% vs 19%); and multi-sensitized (3% vs 15%). Key determinants of sensitization were gender, age, raised on a farm, family history of allergy or asthma, smoking, and occupational exposure to dust or fumes.Fel d 1 and Can f 5 are the most common cat and dog components sensitization in this adult Swedish population. Mono-sensitization is more common than poly-sensitization. This detailed characterization highlights the current distribution of furry animal allergen components in Swedish adults, and their impact on clinical outcomes of asthma will be further explored.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?publicationId=279890
Utskriftsdatum: 2019-11-21