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Visual Function and Fundus Morphology in Relation to Growth and Cardiovascular Status in 10-Year-Old Moderate-to-Late Preterm Children

Artikel i vetenskaplig tidskrift
Författare Alexandra Lind
Jovanna Dahlgren
Lina H. Raffa
Kerstin Allvin
Deala Ghazi Mroué
Marita Andersson Grönlund
Publicerad i American Journal of Ophthalmology
Volym 195
Sidor 121-130
ISSN 0002-9394
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Sidor 121-130
Språk en
Länkar dx.doi.org/10.1016/j.ajo.2018.07.03...
Ämneskategorier Neurovetenskaper

Sammanfattning

Purpose To study visual function and ocular fundus morphology in relation to growth, metabolic status, and blood pressure in moderate-to-late preterm (MLP) children at 10 years of age. Design Prospective cohort study. Methods In this population-based observational study, nonsyndromic MLP children born in Gothenburg, Sweden, were examined neonatally in the years 2002-2003 concerning length, weight, head circumference, and insulin-like growth factor I (IGF-I). At 10 years of age, 33 children (10 girls) were examined regarding previously mentioned variables, and regarding visual acuity, refraction, fundus morphology, IGF binding protein 3, leptin, adiponectin, and blood pressure. An age- and sex-matched control group consisted of 28 children (9 girls). Results Myopia was more commonly found in MLP children than in controls (P = .004, 95% CI 1.8 to 49.8). The MLP group had smaller optic disc area (P = .01, 95% CI −0.5 to −0.1), smaller rim area (P = .001, 95% CI −0.5 to −0.2), fewer branching points (P = .0001, 95% CI −5.7 to −2.1), and higher index of tortuosity of arteries (P = .03, 95% CI 0.002 to 0.03) and veins (P = .02, 95% CI 0.003 to 0.02). Refraction correlated with IGF-I (P = .0005, rs = 0.60 in right eye, and P = .002, rs = 0.55 in left eye) at 10 years of age. Tortuosity of arteries at assessment correlated with neonatal IGF-I levels (P = .03, rs = −0.39). Tortuosity of veins correlated with a leptin/adiponectin ratio at assessment (P = .04, rs = 0.37). Conclusion The findings suggest that being born MLP is associated with myopia, smaller optic disc and rim areas, and abnormal retinal vascularization. Furthermore, metabolic status and growth factors seem to have an impact on ocular development.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?publicationId=274967
Utskriftsdatum: 2019-09-17