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Pneumoproteins and markers of inflammation and platelet activation in the blood of grain dust exposed workers

Artikel i vetenskaplig tidskrift
Författare A. Straumfors
W. Eduard
K. K. Heldal
M. Skogstad
Lars Barregård
D. G. Ellingsen
Publicerad i Biomarkers
Volym 23
Nummer/häfte 8
Sidor 748-755
ISSN 1354-750X
Publiceringsår 2018
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Sidor 748-755
Språk en
Länkar dx.doi.org/10.1080/1354750x.2018.14...
Ämnesord Club cell protein 16, SP-D, bioaerosol exposure, grain elevator workers, compound feed mill workers, clara cell protein, soluble cd40 ligand, norwegian grain, p-selectin, particulate matter, lung-function, serum, cc16, risk, metabolites, Biotechnology & Applied Microbiology, Toxicology
Ämneskategorier Annan klinisk medicin, Lungmedicin och allergi

Sammanfattning

Purpose: To investigate if blood biomarkers could indicate early signs of lung damage or cardiovascular risk due to exposure to grain dust. Materials and methods: Pneumoproteins and markers of inflammation and platelet activation were analysed in blood samples of 102 grain elevator and compound feed mill workers. Differences between exposed (n = 67) and controls (n = 35), and associations with exposure measurements and respiratory health were investigated by multiple linear regression analyses. Results: Concentrations of CC-16 and IL-6 were higher in exposed workers compared with controls (p < 0.001 for both), whereas fibrinogen was lower (p = 0.005). Concentrations of CRP, TNF-alpha, sCD40L and sP-selectin were similar in both groups. Serum CC-16 was significantly higher in workers with farm childhood, regardless of exposure. The impact of farm childhood on CC-16 interacted with smoking. None of the biomarkers were associated with exposure measurements or any of the tested respiratory health parameters. Conclusion: Dust exposure induced inflammatory and anti-inflammatory reactions, but did not induce systemic inflammation and had no effect on platelet activation. No cause-effect relationship could be established in spite of relatively high exposure levels, particularly to endotoxin. Whether increased serum CC-16 is an early sign of lung damage or a reversible defense reaction remains unclear.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?publicationId=274502
Utskriftsdatum: 2019-11-18