Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Mucosal microflora in hea… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Mucosal microflora in head and neck cancer patients

Artikel i vetenskaplig tidskrift
Författare Annica Almståhl
Caterina Finizia
Anette Carlén
Bodil Fagerberg-Mohlin
Torgny Alstad
Publicerad i International Journal of Dental Hygiene
Volym 16
Nummer/häfte 4
Sidor 459-466
ISSN 1601-5029
Publiceringsår 2018
Publicerad vid Institutionen för odontologi
Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar
Sidor 459-466
Språk en
Länkar dx.doi.org/10.1111/idh.12348
Ämnesord buccal mucosa, head and neck cancer patients, hyposalivation, microflora, radiation therapy, tongue, patients receiving radiotherapy, radiation-therapy, oral ecosystems, carcinoma patients, salivary flow, risk-factors, colonization, candidiasis, microbiome, mucositis, Dentistry, Oral Surgery & Medicine
Ämneskategorier Odontologi

Sammanfattning

Objective: To analyse the tongue and buccal microflora prospectively in head and neck cancer patients treated with radiation therapy (RT). Methods: In 33 dentate patients, microbial samples from the tongue and buccal mucosa were collected pretreatment, during treatment, and 6 months, 1 year and 2 years post-treatment. Microorganisms associated with oral health and oral disorders were analysed using cultivation technique. Oral mucositis was scored at the appointment during treatment. Results: Compared with pretreatment, lactobacilli and Candida increased on the tongue, while streptococci and Neisseria decreased during treatment. Two years post-treatment, Neisseria and Prevotella were decreased and Candida increased. On the buccal mucosa, an increased growth of lactobacilli and increased detection frequencies of the opportunistic bacteria Staphylococcus aureus, Gram-negative enteric rods and enterococci were seen during treatment compared with pretreatment. Seventy per cent showed severe mucositis during treatment. Two years post-treatment the total count as well as streptococci, Neisseria and Fusobacterium nucleatum were decreased and lactobacilli increased compared with pretreatment. Conclusion: Despite improvements in treatment for cancer in the head and neck region, microorganisms associated with oral health decrease during treatment and mucosal pathogens increase. Two years post-treatment, levels of acid-tolerant (lactobacilli and Candida) were increased, while acid-sensitive microorganisms (Neisseria and F.nucleatum) were decreased, plausibly due to persisting decreased salivary secretion rate.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?

Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?publicationId=272376
Utskriftsdatum: 2019-07-20