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Non-alcoholic fatty liver disease is a strong predictor of coronary artery calcification in metabolically healthy subjects: A cross-sectional, population-based study in middle-aged subjects

Artikel i vetenskaplig tidskrift
Författare Anders Gummesson
Ulf Strömberg
Caroline Schmidt
J. Kullberg
Oskar Angerås
S. Lindgren
Ola Hjelmgren
Kjell Torén
Annika Rosengren
Björn Fagerberg
J. Brandberg
Göran Bergström
Publicerad i Plos One
Volym 13
Nummer/häfte 8
ISSN 1932-6203
Publiceringsår 2018
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri
Språk en
Länkar dx.doi.org/10.1371/journal.pone.020...
Ämnesord intima-media thickness, type-2 diabetic-patients, cardiovascular-disease, hepatic steatosis, subclinical atherosclerosis, carotid atherosclerosis, computed-tomography, association, calcium, ct, Science & Technology - Other Topics
Ämneskategorier Invärtesmedicin

Sammanfattning

Objectives This study aims to estimate the relationship between non-alcoholic fatty liver disease (NAFLD) and measures of atherosclerotic cardiovascular disease (ASCVD), and to determine to what extent such relationships are modified by metabolic risk factors. The study was conducted in the population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot cohort (n = 1015, age 50-64 years, 51.2% women). NAFLD was defined as computed tomography liver attenuation <= 40 Hounsfield Units, excluding other causes of liver fat. Coronary artery calcification score (CACS) was assessed using the Agatston method. Carotid plaques and intima media thickness (IMT) were measured by ultrasound. Metabolic status was based on assessments of glucose homeostasis, serum lipids, blood pressure and inflammation. A propensity score model was used to balance NAFLD and non NAFLD groups with regards to potential confounders and associations between NAFLD status and ASCVD variables in relation to metabolic status were examined by logistic and generalized linear regression models. NAFLD was present in 106 (10.4%) of the subjects and strongly associated with obesity-related traits. NAFLD was significantly associated with CACS after adjustment for confounders and metabolic risk factors (OR 1.77, 95% CI 1.07-2.94), but not with carotid plaques and IMT. The strongest association between NAFLD and CACS was observed in subjects with few metabolic risk factors (n = 612 [60% of all] subjects with 0-1 out of 7 predefined metabolic risk factors; OR 5.94, 95% CI 2.13-16.6). NAFLD was independently associated with coronary artery calcification but not with measures of carotid atherosclerosis in this cohort. The association between NAFLD and CACS was most prominent in the metabolically healthy subjects.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?publicationId=271519
Utskriftsdatum: 2019-10-19