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Superantigens and adhesins of infant gut commensal Staphylococcus aureus strains and association with subsequent development of atopic eczema.

Artikel i vetenskaplig tidskrift
Författare Forough Nowrouzian
G. Lina
E Hodille
Erika Lindberg
Bill Hesselmar
Robert Saalman
Ingegerd Adlerberth
Agnes E Wold
Publicerad i The British journal of dermatology
Volym 176
Nummer/häfte 2
Sidor 439–445
ISSN 1365-2133
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 439–445
Språk en
Länkar dx.doi.org/10.1111/bjd.15138
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Mikrobiologi, Dermatologi och venereologi, Allergologi

Sammanfattning

According to the hygiene hypothesis, insufficient immune activation by microbes increases the risk of allergy development. Staphylococcus aureus, which is part of the skin and gut microbiota of infants in Western countries, produces a variety of T-cell-activating enterotoxins, called superantigens.To investigate whether early (0-2 months of age) gut colonization by S. aureus strains that carry specific superantigens and adhesins was related to subsequent development of atopic eczema in a Swedish birth cohort.Staphylococcus aureus was isolated from rectal swabs and cultured quantitatively from faecal samples, with individual strains being tested for carriage of genes for superantigens and adhesins. Atopic eczema was diagnosed at onset of symptoms and at 18 months of age.Although the frequency of early gut colonization by S. aureus was not related to subsequent eczema development, the S. aureus strains that were found to colonize those infants who developed atopic eczema were less likely to carry the gene encoding the superantigen SElM (P = 0·008) and the gene for elastin-binding protein (P = 0·03), compared with strains that were isolated from infants who had not developed atopic eczema by 18 months of age.Gut colonization by S. aureus strains carrying a certain combination of superantigen and adhesin genes was negatively associated with subsequent development of atopic eczema. Such strains may provide stimulation and promote maturation of the infant immune system.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?publicationId=248301
Utskriftsdatum: 2019-08-23