Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Neuropathologic Assessmen… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Neuropathologic Assessment of Dementia Markers in Identical and Fraternal Twins

Artikel i vetenskaplig tidskrift
Författare D. Iacono
I. Volkman
I. Nennesmo
N. L. Pedersen
L. Fratiglioni
Boo Johansson
D. Karlsson
B. Winblad
M. Gatz
Publicerad i Brain Pathology
Volym 24
Nummer/häfte 4
Sidor 317-333
ISSN 1015-6305
Publiceringsår 2014
Publicerad vid Psykologiska institutionen
Sidor 317-333
Språk en
Länkar dx.doi.org/10.1111/bpa.12127
Ämnesord AD pathology, aging, ApoE, dementia, monozygotic and dizygotic twins, non-AD co-occurring brain
Ämneskategorier Psykologi, Neurologi

Sammanfattning

Twin studies are an incomparable source of investigation to shed light on genetic and non-genetic components of neurodegenerative diseases, as Alzheimer's disease (AD). Detailed clinicopathologic correlations using twin longitudinal data and post-mortem examinations are mostly missing. We describe clinical and pathologic findings of seven monozygotic (MZ) and dizygotic (DZ) twin pairs. Our findings show good agreement between clinical and pathologic diagnoses in the majority of the twin pairs, with greater neuropathologic concordance in MZ than DZ twins. Greater neuropathologic concordance was found for -amyloid than tau pathology within the pairs. ApoE4 was associated with higher -amyloid and earlier dementia onset, and importantly, higher frequency of other co-occurring brain pathologies, regardless of the zygosity. Dementia onset, dementia duration, difference between twins in age at dementia onset and at death, did not correlate with AD pathology. These clinicopathologic correlations of older identical and fraternal twins support the relevance of genetic factors in AD, but not their sufficiency to determine the pathology, and consequently the disease, even in monozygotic twins. It is the interaction among genetic and non-genetic risks which plays a major role in influencing, or probably determining, the degeneration of those brain circuits associated with pathology and cognitive deficits in AD.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?

Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?publicationId=200578
Utskriftsdatum: 2019-11-17