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Short-Term Exposure to Ozone and Levels of Exhaled Nitric Oxide

Artikel i vetenskaplig tidskrift
Författare L. Modig
Santosh Dahgam
D. Olsson
Fredrik Nyberg
Kristina Wass
B. Forsberg
Anna-Carin Olin
Publicerad i Epidemiology
Volym 25
Nummer/häfte 1
Sidor 79-87
ISSN 1044-3983
Publiceringsår 2014
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Sidor 79-87
Språk en
Länkar dx.doi.org/10.1097/ede.000000000000...
Ämnesord AMBIENT AIR-POLLUTION, LUNG-FUNCTION, ASTHMATIC-CHILDREN, PARTICULATE, MATTER, PULMONARY-FUNCTION, OXIDATIVE STRESS, INFLAMMATION, ADULTS, POPULATION, HEALTH
Ämneskategorier Hälsovetenskaper

Sammanfattning

Background: Adverse effects of air pollution include respiratory inflammation. A few epidemiologic studies have shown elevations in the fraction of exhaled nitric oxide, a marker of airway inflammation, after exposure to traffic-related pollutants. Methods: We examined whether short-term exposures to ozone (O-3), oxides of nitrogen (NOx), or particulate matter <10 m (PM10) were associated with proximal and distal airway inflammation. The study included 5841 randomly selected Swedish adults from 25 to 75 years of age. Fraction of exhaled nitrogen was measured at two flow rates: 50 ml/s representing the proximal airways and 270 ml/s representing the distal airways. Air pollution data were obtained from an urban monitoring site. We applied linear regression to estimate short-term associations of O-3, NOx, and PM10 with fractions of exhaled NO at 50 and 270 ml/s. Results: An interquartile range increase in 120-hour average O-3 levels was associated with a 5.1% (95% confidence interval = 1.7% to 8.5%) higher level of fraction of exhaled NO at 270 ml/s and 3.6% (-0.4% to 3.4%) higher level of the fraction of exhaled NO at 50 ml/s. For NOx, a small effect was seen for the 24-hour average on the fraction of exhaled NO at 270 ml/s, while for PM10 no clear effects were seen. There was a tendency for a weaker effect of ozone and a stronger effect of NOx in subjects with asthma. Conclusions: Exposure to O-3 was associated with a marker of distal airway inflammation, while the association was less obvious for inflammation of the proximal airways.

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Utskriftsdatum: 2019-09-15