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Myofibroblasts in the normal conjunctival surface.

Artikel i vetenskaplig tidskrift
Författare Ximena Aguilar
David Hallberg
Karin Sundelin
Charles Hanson
Kristina Stenberg
Mats Brune
Ulf Stenevi
Publicerad i Acta ophthalmologica
Volym 88
Nummer/häfte 4
Sidor 407-12
ISSN 1755-3768
Publiceringsår 2010
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Institutionen för medicin
Institutionen för medicin, avdelningen för invärtesmedicin
Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
Sidor 407-12
Språk en
Länkar dx.doi.org/10.1111/j.1755-3768.2009...
Ämnesord Actins, metabolism, Adolescent, Adult, Aged, Conjunctiva, cytology, metabolism, Female, Fibroblasts, cytology, metabolism, Fluorescent Antibody Technique, Indirect, Follow-Up Studies, Humans, In Situ Hybridization, Fluorescence, Male, Microscopy, Fluorescence, Middle Aged, Polyploidy, Seasons, Young Adult
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

PURPOSE: To investigate the occurrence of myofibroblasts (MFBs) in the normal conjunctival surface and to evaluate any anatomical and time-related variations. METHODS: MFBs were screened among healthy individuals (35 eyes) by collecting impression cytology (IC) samples from the bulbar conjunctiva. A cohort of volunteers (12 eyes) was followed for 1 year by taking two to five imprints every month. MFBs were identified by immunohistochemical localization of the MFB marker alpha-smooth-muscle actin (alpha-SMA). RESULTS: Using a filter imprint technique, MFBs were found consistently in 94% of samples from the conjunctival surface of participating individuals. The overall MFB levels, expressed as percentage of all cells on the filter, were highest in March-May [mean 4.1%, standard deviation (SD) +/- 1.5] and lowest in December-February (mean 1.2%, SD +/- 0.5). The difference was statistically significant [p < 0.0005, Friedman test, one-way repeated measures analysis of variance (anova)]. Moreover, there was a clear divergence of MFB density between the nasal, temporal, superior and inferior bulbar conjunctiva (mean 1.7%, 1.9%, 22% and 9.7%, respectively). CONCLUSION: MFBs, known as a cellular constituent of granulation tissue in wound healing, occur in the normal conjunctival surface, which is a novel finding. Our results also show that MFB level follows a seasonal variation pattern in a temperate climate, increasing in April-September and decreasing in October-March. This variation might reflect a degree of a transient or ongoing state of tissue repair after conjunctival trauma or stress caused by exposure to environmental factors.

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Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?publicationId=128994
Utskriftsdatum: 2019-06-27