Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Screening for X-linked ad… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Kontaktformulär








 


OBS! Vill du ha svar, ange e-post eller telefonnummer!




Screening for X-linked adrenoleukodystrophy among adult men with Addison's disease

Artikel i vetenskaplig tidskrift
Författare M. A. Horn
M. M. Erichsen
A. S. B. Wolff
Jan-Eric Månsson
E. S. Husebye
C. M. E. Tallaksen
Ola H. Skjeldal
Publicerad i Clinical Endocrinology
Volym 79
Nummer/häfte 3
Sidor 316-320
ISSN 0300-0664
Publiceringsår 2013
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 316-320
Språk en
Länkar dx.doi.org/10.1111/cen.12159
Ämnesord primary adrenal insufficiency, adrenomyeloneuropathy, autoantibodies, dysfunction, experience, childhood
Ämneskategorier Neurologi, Endokrinologi

Sammanfattning

ObjectivesX-linked adrenoleukodystrophy is an important cause of Addison's disease in boys, but less is known about its contribution to Addison's disease in adult men. After surveying all known cases of X-linked adrenoleukodystrophy in Norway in a separate study, we aimed to look for any missed cases among the population of adult men with nonautoimmune Addison's disease. Study designAmong 153 adult men identified in a National Registry for Addison's Disease (75% of identified male cases of Addison's disease in Norway), those with negative indices for 21-hydroxylase autoantibodies were selected. Additionally, cases with low autoantibody indices (48-200) were selected. Sera from subjects included were analysed for levels of very long-chain fatty acids, which are diagnostic for X-linked adrenoleukodystrophy in men. ResultsEighteen subjects had negative indices and 17 had low indices for 21-hydroxylase autoantibodies. None of those with low indices and only one of those with negative indices were found to have X-linked adrenoleukodystrophy; this subject had already been diagnosed because of the neurological symptoms. Cases of Addison's disease proved to be caused by X-linked adrenoleukodystrophy constitute 15% of all adult male cases in Norway; the proportion among nonautoimmune cases was 15%. ConclusionsWe found X-linked adrenoleukodystrophy to be an uncommon cause of Addison's disease in adult men. However, this aetiological diagnosis has far-reaching consequences both for the patient and for his extended family. We therefore recommend that all adult men with nonautoimmune Addison's disease be analysed for levels of very long-chain fatty acids.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?

Denna text är utskriven från följande webbsida:
http://www.gu.se/forskning/publikation/?feedbackForm=true&returnAddress=http%3A%2F%2Fwww.gu.se%2Fforskning%2Fpublikation%2F%3FpublicationId%3D182029&recipientName=Webbredaktion&encodedEmail=YW5uaWthLndhbGxAZ3Uuc2U&publicationId=182029
Utskriftsdatum: 2020-07-13