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Sidan uppdaterades: 2012-09-11 15:12
Författare |
Clas Malmeström Markus Axelsson Jan Lycke Henrik Zetterberg Kaj Blennow Bob Olsson |
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Publicerad i | Journal of neuroimmunology |
Volym | 269 |
Nummer/häfte | 1-2 |
Sidor | 87-9 |
ISSN | 1872-8421 |
Publiceringsår | 2014 |
Publicerad vid |
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi |
Sidor | 87-9 |
Språk | en |
Länkar |
dx.doi.org/10.1016/j.jneuroim.2014.... |
Ämneskategorier | Neurokemi |
The role of glial cells during different phases of multiple sclerosis (MS) is unclear. To monitor glial activation we analyzed the biomarkers YKL-40 and sCD14 in cerebrospinal fluid (CSF) from MS patients during different disease phases and in response to immunosuppressive treatment. CSF levels of YKL-40 were increased in MS during relapse, remission and secondary progression compared with healthy controls. Furthermore, YKL-40 levels in CSF decreased by mitoxantrone and natalizumab treatment. No differences were observed in CSF levels of sCD14. Thus, we can infer that glial activation is present in all MS phases and decreases by immunosuppressive treatment.