Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Experimental exposure to … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Experimental exposure to wood smoke: effects on airway inflammation and oxidative stress.

Artikel i vetenskaplig tidskrift
Författare Lars Barregård
Gerd Sällsten
L Andersson
Ann-Charlotte Almstrand
Pernilla Gustafson
Marianne Andersson
Anna-Carin Olin
Publicerad i Occupational and environmental medicine
Volym 65
Nummer/häfte 5
Sidor 319-24
ISSN 1470-7926
Publiceringsår 2008
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Sidor 319-24
Språk en
Länkar dx.doi.org/10.1136/oem.2006.032458
Ämnesord Adult, Biological Markers, metabolism, Bronchitis, chemically induced, physiopathology, Female, Humans, Inhalation Exposure, adverse effects, Lung, metabolism, physiopathology, Male, Middle Aged, Nitric Oxide, metabolism, Oxidative Stress, Particle Size, Smoke, adverse effects, analysis, Uteroglobin, metabolism, Wood
Ämneskategorier Lungmedicin och allergi

Sammanfattning

BACKGROUND: Particulate air pollution affects cardiovascular and pulmonary disease and mortality. A main hypothesis about the mechanisms involved is that particles induce inflammation in lower airways, systemic inflammation and oxidative stress. OBJECTIVES: To examine whether short-term exposure to wood smoke in healthy subjects affects markers of pulmonary inflammation and oxidative stress. METHODS: 13 subjects were exposed first to clean air and then to wood smoke in a chamber during 4-hour sessions, 1 week apart. The mass concentrations of fine particles at wood smoke exposure were 240-280 mug/m(3), and number concentrations were 95 000-180 000/cm(3), about half of the particles being ultrafine (<100 nm). Blood and breath samples were taken before and at various intervals after exposure to wood smoke and clean air and examined for exhaled nitric oxide and Clara cell protein in serum and urine, and malondialdehyde in exhaled breath condensate. RESULTS: Exposure to wood smoke increased alveolar nitric oxide 3 hours post-exposure while malondialdehyde levels in breath condensate were higher both immediately after and 20 hours after exposure. Serum Clara cell protein was increased 20 hours after exposure. CONCLUSIONS: Wood smoke at levels that can be found in smoky indoor environments caused an inflammatory response and signs of increased oxidative stress in the respiratory tract, especially in the lower airways.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?