Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Recruitment of T cells in… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1.

Artikel i vetenskaplig tidskrift
Författare Bob Olsson
Börje Ridell
Lena M S Carlsson
Stefan Jacobsson
Hans Wadenvik
Publicerad i Blood
Volym 112
Nummer/häfte 4
Sidor 1078-84
ISSN 1528-0020
Publiceringsår 2008
Publicerad vid Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin
Institutionen för biomedicin, avdelningen för patologi
Institutionen för medicin, avdelningen för invärtesmedicin
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 1078-84
Språk en
Länkar dx.doi.org/10.1182/blood-2008-02-13...
Ämnesord Adolescent, Adult, Aged, Bone Marrow, pathology, Cell Movement, Female, Gene Expression Profiling, Humans, Immunity, Integrin alpha4beta1, genetics, Male, Middle Aged, Purpura, Thrombocytopenic, Idiopathic, immunology, Receptors, CXCR4, genetics, Receptors, Chemokine, genetics, T-Lymphocyte Subsets, T-Lymphocytes, physiology, Up-Regulation, genetics
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

In idiopathic thrombocytopenic purpura (ITP), platelets are destroyed in the spleen, liver, and bone marrow (BM) by autoantibodies and cytotoxic T cells. In a DNA microarray screen of peripheral blood T cells, we found that VLA-4, CX3CR1, and CXCR4, involved in T-cell homing, had increased expression in ITP patients compared with controls. However, we only found increased protein expression of VLA-4 on T cells from peripheral blood by flow cytometry. To address a possible recruitment of T cells into the organs involved in platelet destruction, we analyzed T cells in BM. In BM, T-cell surface expression of VLA-4 and CX3CR1 was increased in ITP patients compared with controls. Furthermore, the number of CD3(+) T cells in BM, but not in blood, was increased in ITP patients compared with controls. This finding was confirmed by immunohistochemistry of BM biopsies. The number of regulatory T cells (CD4(+)/CD25(bright)) was decreased in the BM of ITP patients, whereas Fas expression was increased. In conclusion, ITP is associated with accumulation and activation of T cells in the BM. Recruitment of T cells into the target organ (eg, BM) is plausible and may be facilitated through increased VLA-4 and CX3CR1 expression. These molecules might serve as new treatment targets in ITP.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?