Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Lack of androgen receptor… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

Artikel i vetenskaplig tidskrift
Författare F. P. Zhang
M. Malinen
A. Mehmood
T. Lehtiniemi
T. Jaaskelainen
E. A. Niskanen
H. Korhonen
A. Laiho
L. L. Elo
Claes Ohlsson
N. Kotaja
Matti Poutanen
P. Sipila
J. J. Palvimo
Publicerad i Nature Communications
Volym 10
ISSN 2041-1723
Publiceringsår 2019
Publicerad vid Institutionen för medicin
Språk en
Länkar dx.doi.org/10.1038/s41467-019-08730...
Ämnesord mouse epididymis, response element, gene, sumo, ubiquitin, bioconductor, integrity, pathway, health, family, Science & Technology - Other Topics
Ämneskategorier Medicinsk genetik

Sammanfattning

Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or target gene-selective regulation. Here, we generated a mouse model (ArKl) in which the conserved SUMO acceptor lysines of AR are permanently abolished (Ar-K381R, (K500R)) ArKl males develop normally, without apparent defects in their systemic androgen action in reproductive tissues. However, the ArKl males are infertile. Their spermatogenesis appears unaffected, but their epididymal sperm maturation is defective, shown by severely compromised motility and fertilization capacity of the sperm. Fittingly, their epididymal AR chromatin-binding and gene expression associated with sperm maturation and function are misregulated. AR is SUMOylated in the wild-type epididymis but not in the testis, which could explain the tissue-specific response to the lack of AR SUMOylation. Our studies thus indicate that epididymal AR SUMOylation is essential for the post-testicular sperm maturation and normal reproductive capability of male mice.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?