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Aortic diameter at age 65 in men with newly diagnosed type 2 diabetes

Artikel i vetenskaplig tidskrift
Författare S. Taimour
M. Zarrouk
J. Holst
Anders H. Rosengren
L. Groop
P. M. Nilsson
A. Gottsater
Publicerad i Scandinavian Cardiovascular Journal
Volym 51
Nummer/häfte 4
Sidor 202-206
ISSN 1401-7431
Publiceringsår 2017
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 202-206
Språk en
Länkar dx.doi.org/10.1080/14017431.2017.13...
Ämnesord Abdominal aortic aneurysm, aortic diameter, type 2 diabetes, ultrasound, screening, aneurysm screening-program, arterial territories, risk-factors, management, disease, association, mortality, atherosclerosis, epidemiology, dysfunction, Cardiovascular System & Cardiology
Ämneskategorier Epidemiologi, Kardiovaskulär medicin

Sammanfattning

Objectives. Type 2 diabetes mellitus has been linked to a decreased risk for abdominal aortic aneurysm (aortic diameter 30mm, AAA) development in men. The aim of this study was to evaluate if such an effect is detectable already around the time of diabetes diagnosis. Design. We cross-sectionally compared aortic diameter at ultrasound screening for AAA in 691 men aged 65 years with incipient or newly diagnosed type 2 diabetes (group A) with 18,262 65-year old control men without diabetes (group B). Results. Aortic diameter did not differ between groups (18.8[17.4-20.8] vs. 19.0[17.5-28.7] mm; p=0.43). AAA prevalence was 2.5% in group A and 1.5% in group B (p=.010). In logistic regression taking group differences in body mass index (BMI), smoking, presence of atherosclerotic disease and hypertension into account, the difference in AAA prevalence was no longer significant (p=.15). Among men in group A, C-peptide (r=.093; p=.034), but not HbA1c (r=.060; p=.24) correlated with aortic diameter. Conclusion. Among 65 year old men aortic diameter and AAA prevalence do not differ between those with newly diagnosed type 2 diabetes and those without diabetes. Putative protective effects of type 2 diabetes mellitus against aortic dilatation and AAA development therefore probably occur later after diagnosis of diabetes.

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