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Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans

Artikel i vetenskaplig tidskrift
Författare K. Y. Chen
A. M. Cypess
M. R. Laughlin
C. R. Haft
H. H. Hu
M. A. Bredella
Sven Enerbäck
P. E. Kinahan
W. V. Lichtenbelt
F. I. Lin
J. J. Sunderland
K. A. Virtanen
R. L. Wahl
Publicerad i Cell Metabolism
Volym 24
Nummer/häfte 2
Sidor 210-222
ISSN 1550-4131
Publiceringsår 2016
Publicerad vid Institutionen för biomedicin
Sidor 210-222
Språk en
Länkar dx.doi.org/10.1016/j.cmet.2016.07.0...
Ämnesord positron-emission-tomography, type-2 diabetes-mellitus, adult humans, f-18-fdg pet/ct, energy-expenditure, oxidative-metabolism, insulin, sensitivity, computed-tomography, tissue activity, cold-exposure, Cell Biology, Endocrinology & Metabolism
Ämneskategorier Klinisk medicin, Biologiska vetenskaper

Sammanfattning

Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked.

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