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Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador - A cross-shift study of workers at risk of Mesoamerican nephropathy.

Artikel i vetenskaplig tidskrift
Författare Ramón García-Trabanino
Emmanuel Jarquín
Catharina Wesseling
Richard J Johnson
Marvin González-Quiroz
Ilana Weiss
Jason Glaser
Juan José Vindell
Leo Stockfelt
Carlos Roncal
Tamara Harra
Lars Barregård
Publicerad i Environmental research
Volym 142
Sidor 746–755
ISSN 1096-0953
Publiceringsår 2015
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin
Sidor 746–755
Språk en
Länkar dx.doi.org/10.1016/j.envres.2015.07...
Ämnesord Chronic kidney disease; Heat stress;Dehydration; Specific gravity; eGFR; Sugarcane work; Mesoamerican nephropathy; Uric acid
Ämneskategorier Miljömedicin och yrkesmedicin

Sammanfattning

An epidemic of progressive kidney failure afflicts sugarcane workers in Central America. Repeated high-intensity work in hot environments is a possible cause. To assess heat stress, dehydration, biomarkers of renal function and their possible associations. A secondary aim was to evaluate the prevalence of pre-shift renal damage and possible causal factors. Sugarcane cutters (N=189, aged 18–49 years, 168 of them male) from three regions in El Salvador were examined before and after shift. Cross-shift changes in markers of dehydration and renal function were examined and associations with temperature, work time, region, and fluid intake were assessed. Pre-shift glomerular filtration rate was estimated (eGFR) from serum creatinine. The mean work-time was 4 (1.4–11) hours. Mean workday temperature was 34–36 °C before noon, and 39–42 °C at noon. The mean liquid intake during work was 0.8 L per hour. There were statistically significant changes across shift. The mean urine specific gravity, urine osmolality and creatinine increased, and urinary pH decreased. Serum creatinine, uric acid and urea nitrogen increased, while chloride and potassium decreased. Pre-shift serum uric acid levels were remarkably high and pre-shift eGFR was reduced (<60 mL/min) in 23 male workers (14%). The high prevalence of reduced eGFR, and the cross-shift changes are consistent with recurrent dehydration from strenuous work in a hot and humid environment as an important causal factor. The pathophysiology may include decreased renal blood flow, high demands on tubular reabsorption, and increased levels of uric acid.

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