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Prediction of BOS by the single-breath nitrogen test in double lung transplant recipients.

Artikel i vetenskaplig tidskrift
Författare Gerdt C. Riise
Gunnar Mårtensson
Birgitta Houltz
Björn Bake
Publicerad i BMC research notes
Volym 4
Nummer/häfte 1
Sidor 515
ISSN 1756-0500
Publiceringsår 2011
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin
Sidor 515
Språk en
Länkar dx.doi.org/10.1186/1756-0500-4-515
https://gup.ub.gu.se/file/105390
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

BACKGROUND: The present study analyses the ability of the alveolar slope of the single-breath nitrogen washout test (N2-slope) to diagnose and predict the development of the bronchiolitis obliterans syndrome (BOS). METHODS: We present a retrospective analysis of 61 consecutive bilateral lung or heart-lung transplant recipients who were followed at regular control visits during a three year follow-up. The operating characteristics of the N2-slope to diagnose BOS and potential BOS (BOS 0-p) and to predict BOS were determined based on cut off values of 95% specificity. RESULTS: The sensitivity of the N2-slope to identify BOS was 96%, and BOS 0-p 100%. The predictive ability to predict BOS with a N2-slope > 478% of the predicted normal was 56%, and if combined with a coincident FEV1 < 90% of the basal value, the predictive ability was 75%. CONCLUSIONS: The predictive ability of either the N2-slope or of FEV1 to diagnose BOS is limited but the combination of the two appears useful. Follow-up protocols of bilateral lung and heart-lung transplant recipients should consider including tests sensitive to obstruction of the peripheral airways.

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