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Improved energetic recovery of skeletal muscle in response to ischemia and reperfusion injury followed by in vivo 31P-magnetic resonance spectroscopy.

Artikel i vetenskaplig tidskrift
Författare Jonas Lundberg
Ann Lindgård
Anna Elander
Bassam Soussi
Publicerad i Microsurgery
Volym 22
Nummer/häfte 4
Sidor 158-164
ISSN 0738-1085
Publiceringsår 2002
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för plastikkirurgi
Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi
Sidor 158-164
Språk en
Länkar dx.doi.org/10.1002/micr.21744
Ämnesord ischemia, reperfision, irradiation, skeletal muscle, energy, magnetic resonance spectroscopy
Ämneskategorier Medicinska grundvetenskaper

Sammanfattning

It is of great clinical interest to improve postischemic tissue recovery during microsurgical transfers. The effect of singlet oxygen energy (SOE) as photon illumination at 634 nm on rat skeletal muscle during ischemia and postischemic reperfusion was investigated noninvasively and continuously by in vivo 31P-magnetic resonance spectroscopy (31P-MRS). A model of pedicled rat rectus femoris muscle was used, where phosphorous metabolites were followed before onset of ischemia (control), after 4 h of ischemia, and after 1 h of reperfusion. Two groups were studied: one control group (n = 10), and one SOE-treated group (n = 10). Blood perfusion was measured by laser Doppler flowmetry (LDF) during the study. After 4 h of ischemia, ATP levels were 72% and 51% of normal control values in the illuminated group and the control group, respectively (P < 0.05). After 1 h of postischemic reperfusion, phosphocreatine (PCr) recovered to 79% and adenosine triphosphate (ATP) to 71% in the illuminated group, whereas in the control group, the recovery was 57% and 51%, respectively (P < 0.05). It is concluded that singlet oxygen energy has a beneficial effect on the energy state of skeletal muscle during ischemia and postischemic reperfusion. © 2002 Wiley-Liss, Inc. MICROSURGERY 22:158–164 2002

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Utskriftsdatum: 2019-09-17