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Standardisation of OMICS techniques for fish – A necessity for progress and acceptance of results

Paper i proceeding
Författare Göran Dave
Publicerad i SETAC Europe: 20th Annual Meeting, 23-27 May 2010 Seville, Spain PROGRAMME BOOK
Publiceringsår 2010
Publicerad vid Institutionen för växt- och miljövetenskaper
Språk en
Ämnesord fish, omics, toxiciology
Ämneskategorier Kemi, Toxikologi, Toxikologi


Fish play a key role in the function of aquatic ecosystems being both predators and prey. Fish are also of key importance as a human food resource and, thus, economically important. Fish are also genetically and physiologically closely related to man and other vertebrates. This means that fish are favoured research animals in physiological studies and integral parts in hazard and risk assessment programs. Fish are also very useful for testing of sublethal effects and monitoring of individual health through the application of methods developed for clinical investigations on humans and domestic animals. This means that fish can be used as a link between hazard (toxicity) assessments and risk (environmental) assessments. It is well known that comparability of results and trust in test and monitoring methods are extremily important. Data bases with comparable toxicity test results are for instance essential for determinations and evaluations of species sensitivity distributions and QSAR models. This is not least important in the implementation of Reach. Standardisation of sampling methods is also essential in assessment and monitoring of ecosystem health, i.e. the risk for environmental perturbation and assessment and classification of water bodies according to the European Water Framework Directive. Thus, standardisation of methods plays a key role for confidence and trust in all measurements and test results. Contrary to what many scientists believe the aim of standardisation is to standardise as little as possible – only what is necessary. The aim of this paper is to highlight the need for standardisation of important parts of the omics techniques and to get input from OMIC researchers into this process within ISO/TC145/SC5/WG3 Toxicity-Fish.

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