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Evaluating amyloid-β oligomers in cerebrospinal fluid as a biomarker for Alzheimer's disease.

Artikel i vetenskaplig tidskrift
Författare Mikko Hölttä
Oskar Hansson
Ulf Andreasson
Joakim Hertze
Lennart Minthon
Katarina Nägga
Niels Andreasen
Henrik Zetterberg
Kaj Blennow
Publicerad i PloS one
Volym 8
Nummer/häfte 6
Sidor e66381
ISSN 1932-6203
Publiceringsår 2013
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor e66381
Språk en
Länkar dx.doi.org/10.1371/journal.pone.006...
Ämneskategorier Neurokemi

Sammanfattning

The current study evaluated amyloid-β oligomers (Aβo) in cerebrospinal fluid as a clinical biomarker for Alzheimer's disease (AD). We developed a highly sensitive Aβo ELISA using the same N-terminal monoclonal antibody (82E1) for capture and detection. CSF samples from patients with AD, mild cognitive impairment (MCI), and healthy controls were examined. The assay was specific for oligomerized Aβ with a lower limit of quantification of 200 fg/ml, and the assay signal showed a tight correlation with synthetic Aβo levels. Three clinical materials of well characterized AD patients (n = 199) and cognitively healthy controls (n = 148) from different clinical centers were included, together with a clinical material of patients with MCI (n = 165). Aβo levels were elevated in the all three AD-control comparisons although with a large overlap and a separation from controls that was far from complete. Patients with MCI who later converted to AD had increased Aβo levels on a group level but several samples had undetectable levels. These results indicate that presence of high or measurable Aβo levels in CSF is clearly associated with AD, but the overlap is too large for the test to have any diagnostic potential on its own.

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