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Children's stress-related reports and stress biomarkers interact in their association with metabolic syndrome risk

Artikel i vetenskaplig tidskrift
Författare N. Michels
D. Matthys
B. Thumann
Staffan Mårild
S. De Henauw
Publicerad i Stress and Health
Volym 34
Nummer/häfte 4
Sidor 523-533
ISSN 1532-3005
Publiceringsår 2018
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 523-533
Språk en
Länkar dx.doi.org/10.1002/smi.2813
Ämnesord autonomic nervous system, cardiovascular disease prevention, cortisol, metabolic health, heart-rate-variability, pituitary-adrenal axis, body-mass index, salivary cortisol, obese children, hypercortisolemic depression, physical-activity, serum cortisol, blood-pressure, adolescents, Psychology, Psychiatry, rousos gp, 1992, jama-journal of the american medical association, v267, p1244, rges sw, 1995, neuroscience and biobehavioral reviews, v19, p225
Ämneskategorier Barn- och ungdomspsykiatri, Psykiatri, Psykologi

Sammanfattning

The purpose was to examine the cross-sectional associations of stress-related reports and stress biomarkers with metabolic syndrome (MetS) risk in children while also testing the interaction between stress biomarkers and stress reports. In 353 children (5-10years old, 7.9% overweight/obese), MetS risk was measured by blood pressure, waist circumference, glucose homeostasis, triglycerides, and high-density cholesterol. Stress was measured by stress-related reports (events, emotions, and internalizing/externalizing problems) and two biomarkers: salivary cortisol (total-day and morning output) and heart rate variability (percentage of consecutive normal RR intervals differing more than 50ms and low-to-high-frequency ratio). Cross-sectional regression analyses with z scored total MetS risk as outcome were adjusted for age, sex, and socio-economic status. Only internalizing problems were directly related to a higher MetS risk score (=0.236). Cortisol and heart rate variability were significant moderators: High cortisol morning output resulted in a positive (unfavourable) report-MetS relationship (=0.259-0.552), whereas low percentage of consecutive normal RR intervals differing more than 50ms resulted in a negative (favourable) report-MetS relationship (=-0.298) and low low-to-high-frequency ratio in a positive (unfavourable) report-MetS relationship (=0.478). In conclusion, stress can sometimes be a disadvantageous factor in metabolic health of otherwise healthy children. The cortisol biomarker seems relevant because metabolic risk was highest when stress-related reports were accompanied by high morning cortisol output.

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