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The relationship between cerebrospinal fluid biomarkers and depression in elderly women.

Artikel i vetenskaplig tidskrift
Författare Pia Gudmundsson
Ingmar Skoog
Margda Waern
Kaj Blennow
Sigurdur Palsson
Lars Rosengren
Deborah Gustafson
Publicerad i The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Volym 15
Nummer/häfte 10
Sidor 832-8
ISSN 1064-7481
Publiceringsår 2007
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 832-8
Språk en
Länkar dx.doi.org/10.1097/JGP.0b013e318054...
Ämnesord Age Factors, Aged, Aged, 80 and over, Albumins, cerebrospinal fluid, Alzheimer Disease, cerebrospinal fluid, epidemiology, Amyloid beta-Protein, cerebrospinal fluid, Biological Markers, cerebrospinal fluid, Blood-Brain Barrier, metabolism, Cross-Sectional Studies, Depressive Disorder, Major, cerebrospinal fluid, diagnosis, epidemiology, Diagnosis, Differential, Female, Geriatric Assessment, Humans, Nerve Degeneration, metabolism, Psychiatric Status Rating Scales, Serum Albumin, analysis, Spinal Puncture, Sweden, epidemiology, tau Proteins, cerebrospinal fluid
Ämneskategorier Psykiatri

Sammanfattning

OBJECTIVE: Cerebrospinal fluid (CSF) biomarkers including the 42 amino-acid form of beta-amyloid (Abeta42), total tau protein (T-tau), and the CSF/serum albumin ratio are markers of brain pathology and metabolism. Abeta42 and T-tau are sometimes used to discriminate geriatric depression from mild forms of Alzheimer disease (AD) in clinical studies. However, studies focusing on the relationship between these CSF biomarkers and geriatric depression are lacking. METHODS: This was a cross-sectional study with a population-based sample of 84 nondemented elderly women in Sweden. Measurements included neuropsychiatric, physical, and lumbar puncture examinations, with Diagnostic and Statistical Manual of Mental Disorders, Third Revision-based depression diagnoses and measurement of CSF levels of Abeta42, T-tau, albumin, and serum albumin. RESULTS: Fourteen women (mean age: 72.6 years) had any depression (11 with major depressive disorder [MDD]). Compared to women without depression, women with MDD had higher levels of Abeta42 and the CSF/serum albumin ratio. The CSF/serum albumin ratio was also higher in women with any depression. No differences in T-tau were observed; however, T-tau increased with age. CONCLUSION: Higher levels of CSF Abeta42 were observed among elderly depressed women, in contrast to lower levels usually observed in AD, indicating potential neuropathological differences between the two disorders. Higher CSF/serum albumin ratios observed in depressed women point to potential vascular processes.

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