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Longstanding psychological stress in relation to biomarkers of neuronal dysfunction in cerebrospinal fluid: a 25-year follow-up study in women

Artikel i vetenskaplig tidskrift
Författare Lena Johansson
Simona Sacuiu
Silke Kern
Xinxin Guo
Henrik Zetterberg
Kaj Blennow
Anna Zettergren
Ingmar Skoog
Publicerad i Neurobiology of Aging
Volym 80
Sidor 111-115
ISSN 0197-4580
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Centrum för åldrande och hälsa (AgeCap)
Sidor 111-115
Språk en
Länkar dx.doi.org/10.1016/j.neurobiolaging...
Ämnesord Stress, Neuropathology, Neurodegeneration, Cerebrospinal fluid, Aging, alzheimers-disease, cognitive decline, brain atrophy, population, protein, risk, personality, distress, dementia, markers, Geriatrics & Gerontology, Neurosciences & Neurology, leans, la, v886, p172
Ämneskategorier Neurovetenskaper

Sammanfattning

Longstanding psychological stress has been associated with increased risk of neurodegenerative disorders, such as dementia and Alzheimer's disease. In a prospective population study of women (n = 81), we tested if midlife stress (mean age 49 years) was associated with late-life biomarkers of neuro-degeneration in cerebrospinal fluid (CSF) (mean age 74 years) in linear regression models. It was found that women who report of stress at baseline (n = 20) had higher levels of CSF visinin-like protein-1 (VILIP-1) (age adjusted beta = 0.113, p = 0.017) and CSF myelin basic protein (beta = 0.060, p = 0.030) compared with women without midlife stress (n = 61). There was also a trend observed for higher CSF neurofilament light (beta = 0.133, p = 0.056). In addition, longer periods of stress (i.e., stress at 2-3 midlife examinations) were associated with higher levels of CSF VILIP-1. The results suggest that longstanding stress might be associated with neurodegenerative processes in the brain, as CSF VILIP-1 is an unspecific marker for neuronal injury and CSF myelin basic protein reflects neuroaxonal demyelination. (C) 2019 Elsevier Inc. All rights reserved.

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