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Visceral sensitivity remains stable over time in patients with irritable bowel syndrome, but with individual fluctuations

Artikel i vetenskaplig tidskrift
Författare Axel Josefsson
Amanda Rosendahl
Pernilla Jerlstad
Gunilla Näslin
Hans Törnblom
Magnus Simrén
Publicerad i Neurogastroenterology and Motility
Volym 31
Nummer/häfte 7
ISSN 1350-1925
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Språk en
Länkar dx.doi.org/10.1111/nmo.13603
Ämnesord irritable bowel syndrome, quality of life, visceral hypersensitivity
Ämneskategorier Invärtesmedicin

Sammanfattning

Background: Visceral hypersensitivity in irritable bowel syndrome (IBS), measured with rectal balloon distensions, using a barostat, has been suggested to be a phenomenon that is reduced due to habituation at repeated investigations. We investigated the stability of rectal sensitivity in patients with IBS who had undergone a previous rectal barostat study and assessed variations in symptom pattern and severity in relation to rectal sensory function. Method: Irritable bowel syndrome patients, who had previously been undergone a rectal barostat study, were included. All patients underwent a second study 8-12 years later. Symptoms were characterized by use of questionnaires. Key Results: We included 26 subjects (17 females, median age at the index investigation 44.5 (21-61) years). Pressure and volume sensory thresholds were unchanged at the follow-up compared with the index investigation (P > 0.05 for all). At the index investigation, 8/26 patients had rectal hypersensitivity of which four were reclassified as normosensitive, and sixfrom normo- to hypersensitive, meaning that 10/26 patients were hypersensitive at the follow-up investigation. IBS-QOL had improved significantly in six of nine domains at follow-up (P < 0.05 for all). There were no differences in anxiety, depression, IBS symptom severity, or somatization (P > 0.05) at follow-up. None of these were associated with change in rectal sensitivity at follow-up. Conclusions and Inferences: Rectal hypersensitivity and IBS symptoms remained stable at the group level over 8-12 years in IBS patients, even though individual fluctuations were noted. Our findings contradict previous findings indicating that visceral hypersensitivity is an unstable trait. © 2019 John Wiley & Sons Ltd

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