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Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

Artikel i övriga tidskrifter
Författare Aled Clayton
Dominik Buschmann
J. Brian Byrd
David R.F. Carter
Lesley Cheng
Carolyn Compton
George Daaboul
Andrew Devitt
Juan Manuel Falcon-Perez
Chris Gardiner
Dakota Gustafson
Paul Harrison
Clemens Helmbrecht
An Hendrix
Andrew Hill
Andrew Hoffman
Jennifer C. Jones
Raghu Kalluri
Ji Yoon Kang
Benedikt Kirchner
Cecilia Lässer
Charlotte Lawson
Metka Lenassi
Carina Levin
Alicia Llorente
Elena S. Martens-Uzunova
Andreas Möller
Luca Musante
Takahiro Ochiya
Ryan C. Pink
Hidetoshi Tahara
Marca H.M. Wauben
Jason P. Webber
Joshua A. Welsh
Kenneth W. Witwer
Hang Yin
Rienk Nieuwland
Publicerad i Journal of Extracellular Vesicles
Volym 7
Publiceringsår 2018
Publicerad vid Krefting Research Centre
Språk en
Länkar doi.org/10.1080/20013078.2018.14737...
Ämnesord Biomarkers, cancer, exosomes, extracellular vesicles, plasma, serum, urine
Ämneskategorier Cellbiologi

Sammanfattning

© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles. This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

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