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In vitro evaluation of barrier function against oral bacteria of dense and expanded polytetrafluoroethylene (PTFE) membranes for guided bone regeneration

Artikel i vetenskaplig tidskrift
Författare Margarita Trobos
Annika Juhlin
Furqan A. Shah
Maria Hoffman
H. Sahlin
Christer Dahlin
Publicerad i Clinical Implant Dentistry and Related Research
Volym 20
Nummer/häfte 5
Sidor 738-748
ISSN 1523-0899
Publiceringsår 2018
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 738-748
Språk en
Länkar dx.doi.org/10.1111/cid.12629
Ämnesord biofilm, d-PTFE, e-PTFE, GBR, guided bone regeneration, membrane, PTFE, Streptococcus oralis, biofilm formation, streptococcus-oralis, ridge augmentation, tissue, regeneration, collagen, metaanalysis, roughness, implants, surfaces, adhesion, Dentistry, Oral Surgery & Medicine
Ämneskategorier Odontologi

Sammanfattning

Aim: This study evaluates biofilm formation and barrier function against Streptococcus oralis of nonresorbable polytetrafluoroethylene (PTFE) guided bone regeneration membranes having expanded (e-PTFE) and dense (d-PTFE) microstructure. Materials and Methods: Three e-PTFE membranes of varying openness, one d-PTFE membrane, and commercially pure titanium discs were evaluated. All e-PTFE membranes consisted of PTFE nodes interconnected by fibrils. The d-PTFE membrane was fibril-free, with large evenly spaced indentations. The surfaces were challenged with S. oralis and incubated statically for 2-48 h. Bacterial colonization, viability, and penetration were evaluated. Results: S. oralis numbers increased over time on all surfaces, as observed using scanning electron microscopy, while cell viability decreased, as measured by colony forming unit (CFU) counting. At 24 h and 48 h, biofilms on d-PTFE were more mature and thicker (tower formations) than on e-PTFE, where fewer layers of cells were distributed mainly horizontally. Biofilms accumulated preferentially within d-PTFE membrane indentations. At 48 h, greater biofilm biomass and number of viable S. oralis were found on d-PTFE compared to e-PTFE membranes. All membranes were impermeable to S. oralis cells. Conclusions: All PTFE membranes were effective barriers against bacterial passage in vitro. However, d-PTFE favored S. oralis biofilm formation.

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